Taotao Liu1, Qinyu Zhao2, Bin Du3. 1. Department of Surgical Intensive Care Unit, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China. 2. College of Engineering and Computer Science, Australian National University, Canberra, 2600, Australia. 3. Department of Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 1 Shuai Fu Yuan, Beijing, 100730, China. dubin98@gmail.com.