| Literature DB >> 34107025 |
Laura Pérez Lago1,2, Helena Martínez Lozano2,3, Jose Antonio Pajares Díaz2,3, Arantxa Díaz Gómez2,3, Marina Machado1,2, Pedro J Sola-Campoy1,2, Marta Herranz1,2,4, Sergio Buenestado-Serrano1,2, Maricela Valerio1,2, María Olmedo1,2, Cristina Andrés Zayas2,5, Iñaki Comas6,7, Fernando González Candelas7,8, Rafael Bañares9,10, Pilar Catalán1,2,4, Patricia Muñoz1,2,4,9, Darío García de Viedma1,2,4.
Abstract
A 77-year-old-male (Case R) who had had a previous diagnosis of mild COVID-19 episode, was hospitalized 35 days later. On Day 23 post-admission, he developed a second COVID-19 episode, now severe, and finally died. Initially, Case R COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive room-mate. However, whole-genome-sequencing indicated that case R recurrence corresponded to a reactivation of the strain involved in his first episode. Case R reactivation had major consequences, leading to a more severe episode, and causing a subsequent transmission to another two hospitalized patients, one of them with fatal outcome.Entities:
Keywords: COVID-19; SARS-CoV-2; WGS; nosocomial transmission; reactivation
Year: 2021 PMID： 34107025 DOI： 10.1093/infdis/jiab302
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226