Nazlı Pınar Karahan Şen1, Ayşegül Aksu2, Gamze Çapa Kaya3. 1. Department of Nuclear Medicine, Dokuz Eylul University Faculty of Medicine, İnciraltı mah. Mithatpaşa cad. no:1606 Balçova, Izmir, Turkey. drpinarkarahan@hotmail.com. 2. Başakşehir Çam ve Sakura City Hospital, Department of Nuclear Medicine, Istanbul, Turkey. 3. Department of Nuclear Medicine, Dokuz Eylul University Faculty of Medicine, İnciraltı mah. Mithatpaşa cad. no:1606 Balçova, Izmir, Turkey.
Abstract
OBJECTIVE: This study evaluates the ability of several machine learning (ML) algorithms, developed using volumetric and texture data extracted from baseline 18F-FDG PET/CT studies performed initial staging of patient with esophageal cancer (EC), to predict survival and histopathology. METHODS: The initial staging 18F-FDG PET/CT images obtained on newly diagnosed EC patients between January 2008 and June 2019 were evaluated using LIFEx software. A region of interest (ROI) of the primary tumor was created and volumetric and textural features were obtained. A significant relationship between these features and pathological subtypes, 1-year, and 5-year survival was investigated. Due to the nonhomogeneity of the data, nonparametric test (The Mann-Whitney U test) was used for each feature, in pairwise comparisons of independent variables. A p value of < 0.05 was considered significant. Receiver operating curve (ROC) analysis was performed for features with p < 0.05. Correlation between the significant features was evaluated with Spearman correlation test; features with correlation coefficient < 0.8 were evaluated with several ML algorithms. RESULTS: In predicting survival in a 1-year follow-up J48 was obtained as the most successful algorithm (AUC: 0.581, PRC: 0.565, MCC: 0.258, acc: 64.29%). 5-year survival results were more promising than 1-year survival results with (AUC: 0.820, PRC: 0.860, MCC: 271, acc: 81.36%) by logistic regression. It is revealed that the most successful algorithm was naive bayes (AUC: 0.680 PRC: 0.776, MCC: 0.298, acc: 82.66%) in the histopathological discrimination. CONCLUSION: Texture analysis with ML algorithms could be predictive of overall survival and discriminating histopathological subtypes of EC.
OBJECTIVE: This study evaluates the ability of several machine learning (ML) algorithms, developed using volumetric and texture data extracted from baseline 18F-FDG PET/CT studies performed initial staging of patient with esophageal cancer (EC), to predict survival and histopathology. METHODS: The initial staging 18F-FDG PET/CT images obtained on newly diagnosed EC patients between January 2008 and June 2019 were evaluated using LIFEx software. A region of interest (ROI) of the primary tumor was created and volumetric and textural features were obtained. A significant relationship between these features and pathological subtypes, 1-year, and 5-year survival was investigated. Due to the nonhomogeneity of the data, nonparametric test (The Mann-Whitney U test) was used for each feature, in pairwise comparisons of independent variables. A p value of < 0.05 was considered significant. Receiver operating curve (ROC) analysis was performed for features with p < 0.05. Correlation between the significant features was evaluated with Spearman correlation test; features with correlation coefficient < 0.8 were evaluated with several ML algorithms. RESULTS: In predicting survival in a 1-year follow-up J48 was obtained as the most successful algorithm (AUC: 0.581, PRC: 0.565, MCC: 0.258, acc: 64.29%). 5-year survival results were more promising than 1-year survival results with (AUC: 0.820, PRC: 0.860, MCC: 271, acc: 81.36%) by logistic regression. It is revealed that the most successful algorithm was naive bayes (AUC: 0.680 PRC: 0.776, MCC: 0.298, acc: 82.66%) in the histopathological discrimination. CONCLUSION: Texture analysis with ML algorithms could be predictive of overall survival and discriminating histopathological subtypes of EC.