Augusto Di Castelnuovo1, Simona Costanzo2, Marialaura Bonaccio2, Patrick McElduff3, Allan Linneberg4, Veikko Salomaa5, Satu Männistö5, Marie Moitry6, Jean Ferrières7, Jean Dallongeville8, Barbara Thorand9, Hermann Brenner10, Marco Ferrario11, Giovanni Veronesi11, Emanuela Pettenuzzo11, Abdonas Tamosiunas12, Inger Njølstad13, Wojciech Drygas14, Yuri Nikitin15, Stefan Söderberg16, Frank Kee17, Guido Grassi18, Dirk Westermann19, Benedikt Schrage19, Salim Dabboura19, Tanja Zeller19, Kari Kuulasmaa5, Stefan Blankenberg19, Maria Benedetta Donati2, Giovanni de Gaetano2, Licia Iacoviello2,11. 1. Mediterranea Cardiocentro, Napoli, Italy. 2. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy. 3. University of Newcastle & Hunter Medical Research Institute, Australia. 4. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 5. Finnish Institute for Health and Welfare, Helsinki, Finland. 6. Department of Public Health, University Hospital of Strasbourg and Department of Epidemiology and Public Health, University of Strasbourg, France. 7. Department of Cardiology and INSERM UMR 1295, Toulouse University Hospital, Toulouse, France. 8. University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France. 9. Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany. 10. Division of Clinical Epidemiology and Aging Research and Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany. 11. Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy. 12. Lithuanian University of Health Sciences, Kaunas, Lithuania. 13. Department of community Medicine, University of Tromsø - the Arctic University of Norway, Norway. 14. Department of Epidemiology CVD Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland. 15. The Institute of Internal and Preventive Medicine, Novosibirsk, Russia. 16. Department of Public Health and Clinical Medicine, and Heart Centre, Umeå University, Sweden. 17. Centre for Public Health, Queens University of Belfast, Belfast, Northern Ireland. 18. Clinica Medica, Università Milano-Bicocca, Milano, Italy. 19. Clinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany.
Abstract
AIM: To test the association of alcohol consumption with total and cause-specific mortality risk. DESIGN: Prospective observational multi-centre population-based study. SETTING: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. PARTICIPANTS: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men). MEASUREMENTS: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality. FINDINGS: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7-14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively. CONCLUSIONS: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
AIM: To test the association of alcohol consumption with total and cause-specific mortality risk. DESIGN: Prospective observational multi-centre population-based study. SETTING: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. PARTICIPANTS: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men). MEASUREMENTS: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality. FINDINGS: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7-14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively. CONCLUSIONS: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
Authors: David J Cote; Timothy R Smith; Ursula B Kaiser; Edward R Laws; Meir J Stampfer Journal: Cancer Causes Control Date: 2022-01-04 Impact factor: 2.532
Authors: Ricardas Radisauskas; Kawon Victoria Kim; Shannon Lange; Vaida Liutkute-Gumarov; Olga Mesceriakova-Veliuliene; Janina Petkeviciene; Mindaugas Stelemekas; Tadas Telksnys; Alexander Tran; Jürgen Rehm Journal: BMC Public Health Date: 2021-11-17 Impact factor: 3.295