Literature DB >> 34102097

Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany.

Tatjana Schwarz, Pinkus Tober-Lau, David Hillus, Elisa T Helbig, Lena J Lippert, Charlotte Thibeault, Willi Koch, Irmgard Landgraf, Janine Michel, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Chantip Dang-Heine, Stefanie Kasper, Friederike Münn, Kai Kappert, Andreas Nitsche, Rudolf Tauber, Sein Schmidt, Piotr Kopankiewicz, Harald Bias, Joachim Seybold, Christof von Kalle, Terry C Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander, Victor M Corman, Florian Kurth.   

Abstract

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.

Entities:  

Keywords:  B cell; Berlin; COVID-19; Germany; SARS-CoV-2; T cell; antibody; coronavirus disease; immunity; mRNA; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine; viruses; zoonoses

Mesh：

Substances：

Year:  2021        PMID： 34102097     DOI： 10.3201/eid2708.211145

Source DB:  PubMed          Journal:  Emerg Infect Dis        ISSN： 1080-6040            Impact factor:   6.883


  29 in total

1.  B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients.

Authors:  Eva Schrezenmeier; Hector Rincon-Arevalo; Ana-Luisa Stefanski; Alexander Potekhin; Henriette Straub-Hohenbleicher; Mira Choi; Friederike Bachmann; Vanessa Pross; Charlotte Hammett; Hubert Schrezenmeier; Carolin Ludwig; Bernd Jahrsdörfer; Andreia Lino; Kai-Uwe Eckardt; Katja Kotsch; Thomas Dörner; Klemens Budde; Arne Sattler; Fabian Halleck
Journal:  J Am Soc Nephrol       Date:  2021-10-19       Impact factor: 10.121

Review 2.  Immunity after COVID-19 vaccination in people with higher risk of compromised immune status: a scoping review.

Authors:  Nina Kreuzberger; Caroline Hirsch; Marike Andreas; Lena Böhm; Paul J Bröckelmann; Veronica Di Cristanziano; Martin Golinski; Renate Ilona Hausinger; Sibylle Mellinghoff; Berit Lange; Tina Lischetzki; Verena Kappler; Agata Mikolajewska; Ina Monsef; Yun Soo Park; Vanessa Piechotta; Christoph Schmaderer; Miriam Stegemann; Kanika Vanshylla; Florencia Weber; Stephanie Weibel; Caspar Stephani; Nicole Skoetz
Journal:  Cochrane Database Syst Rev       Date:  2022-08-09

Review 3.  Janus kinase inhibitors for the treatment of COVID-19.

Authors:  Andre Kramer; Carolin Prinz; Falk Fichtner; Anna-Lena Fischer; Volker Thieme; Felicitas Grundeis; Manuel Spagl; Christian Seeber; Vanessa Piechotta; Maria-Inti Metzendorf; Martin Golinski; Onnen Moerer; Caspar Stephani; Agata Mikolajewska; Stefan Kluge; Miriam Stegemann; Sven Laudi; Nicole Skoetz
Journal:  Cochrane Database Syst Rev       Date:  2022-06-13

4.  Heterologous high dose SARS-CoV-2 mRNA vaccine booster may improve immune response in seronegative kidney transplant recipients.

Authors:  Leszek Tylicki; Bogdan Biedunkiewicz; Zuzanna Ślizień; Marta Muchlado; Alicja Dębska-Ślizień
Journal:  Arch Med Sci       Date:  2022-06-23       Impact factor: 3.707

Review 5.  Long-Term Immunity and Antibody Response: Challenges for Developing Efficient COVID-19 Vaccines.

Authors:  Mohammad Reza Sepand; Banafsheh Bigdelou; Jim Q Ho; Mohammad Sharaf; Alexis J Lannigan; Ian M Sullivan; Alecsander P da Silva; Leland O Barrett; Scott McGoldrick; Yuvraj Lnu; Shannon E Lynch; Jared M Boisclair; Dakarai D Barnard-Pratt; Steven Zanganeh
Journal:  Antibodies (Basel)       Date:  2022-05-12

Review 6.  Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity.

Authors:  Bart N Ford; Jonathan Savitz
Journal:  Immun Ageing       Date:  2022-07-14       Impact factor: 9.701

7.  Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.

Authors:  David Hillus; Tatjana Schwarz; Pinkus Tober-Lau; Kanika Vanshylla; Hana Hastor; Charlotte Thibeault; Stefanie Jentzsch; Elisa T Helbig; Lena J Lippert; Patricia Tscheak; Marie Luisa Schmidt; Johanna Riege; André Solarek; Christof von Kalle; Chantip Dang-Heine; Henning Gruell; Piotr Kopankiewicz; Norbert Suttorp; Christian Drosten; Harald Bias; Joachim Seybold; Florian Klein; Florian Kurth; Victor Max Corman; Leif Erik Sander
Journal:  Lancet Respir Med       Date:  2021-08-13       Impact factor: 30.700

8.  Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis.

Authors:  Eva Schrezenmeier; Leon Bergfeld; David Hillus; Joerg-Detlev Lippert; Ulrike Weber; Pinkus Tober-Lau; Irmgard Landgraf; Tatjana Schwarz; Kai Kappert; Ana-Luisa Stefanski; Arne Sattler; Katja Kotsch; Thomas Dörner; Leif Erik Sander; Klemens Budde; Fabian Halleck; Florian Kurth; Victor Max Corman; Mira Choi
Journal:  Front Immunol       Date:  2021-06-30       Impact factor: 7.561

9.  Remdesivir for the treatment of COVID-19.

Authors:  Kelly Ansems; Felicitas Grundeis; Karolina Dahms; Agata Mikolajewska; Volker Thieme; Vanessa Piechotta; Maria-Inti Metzendorf; Miriam Stegemann; Carina Benstoem; Falk Fichtner
Journal:  Cochrane Database Syst Rev       Date:  2021-08-05

10.  Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021.

Authors:  Pinkus Tober-Lau; Tatjana Schwarz; David Hillus; Jana Spieckermann; Elisa T Helbig; Lena J Lippert; Charlotte Thibeault; Willi Koch; Leon Bergfeld; Daniela Niemeyer; Barbara Mühlemann; Claudia Conrad; Stefanie Kasper; Friederike Münn; Frank Kunitz; Terry C Jones; Norbert Suttorp; Christian Drosten; Leif Erik Sander; Florian Kurth; Victor M Corman
Journal:  Emerg Infect Dis       Date:  2021-06-08       Impact factor: 6.883
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