Literature DB >> 34102066

Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection.

James B Hurley1.   

Abstract

The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O2, glucose, and other nutrients diffuse out of the choroid and then filter through a monolayer of retinal pigment epithelium (RPE) cells to fuel the retina. Recent studies of energy metabolism have revealed striking differences between retinas and RPE cells in the ways that they extract energy from fuels. The purpose of this review is to suggest and evaluate the hypothesis that the retina and RPE have complementary metabolic roles that make them depend on each other for survival and for their abilities to perform essential and specialized functions.

Entities:  

Keywords:  metabolism; photoreceptors; retina; retinal pigment epithelium

Mesh：

Year:  2021        PMID： 34102066      PMCID： PMC8922051          DOI： 10.1146/annurev-vision-100419-115156

Source DB:  PubMed          Journal:  Annu Rev Vis Sci        ISSN： 2374-4642            Impact factor:   6.422


  170 in total

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2.  Proline mediates metabolic communication between retinal pigment epithelial cells and the retina.

Authors:  Michelle Yam; Abbi L Engel; Yekai Wang; Siyan Zhu; Allison Hauer; Rui Zhang; Daniel Lohner; Jiancheng Huang; Marlee Dinterman; Chen Zhao; Jennifer R Chao; Jianhai Du
Journal:  J Biol Chem       Date:  2019-05-19       Impact factor: 5.157

Review 3.  Mitochondrial Defects Drive Degenerative Retinal Diseases.

Authors:  Deborah A Ferrington; Cody R Fisher; Renu A Kowluru
Journal:  Trends Mol Med       Date:  2019-11-23       Impact factor: 11.951

4.  Glucose metabolism in pig outer retina in light and darkness.

Authors:  L Wang; P Törnquist; A Bill
Journal:  Acta Physiol Scand       Date:  1997-05

5.  Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B).

Authors:  Lauren L Daniele; Jennifer Caughey; Stefanie Volland; Rachel C Sharp; Anuradha Dhingra; David S Williams; Nancy J Philp; Kathleen Boesze-Battaglia
Journal:  Am J Physiol Cell Physiol       Date:  2019-10-02       Impact factor: 4.249

6.  Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling.

Authors:  Sidney M Gospe; Amanda M Travis; Alexander V Kolesnikov; Mikael Klingeborn; Luyu Wang; Vladimir J Kefalov; Vadim Y Arshavsky
Journal:  J Biol Chem       Date:  2019-06-27       Impact factor: 5.157

7.  Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia.

Authors:  C Vijayasarathy; Shirish Damle; Subbuswamy K Prabu; Cynthia M Otto; Narayan G Avadhani
Journal:  Eur J Biochem       Date:  2003-03

8.  High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.

Authors:  Una L Kelly; Daniel Grigsby; Martha A Cady; Michael Landowski; Nikolai P Skiba; Jian Liu; Alan T Remaley; Mikael Klingeborn; Catherine Bowes Rickman
Journal:  J Biol Chem       Date:  2020-07-31       Impact factor: 5.157

9.  Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model.

Authors:  Adam M Hanif; Eric C Lawson; Megan Prunty; Marissa Gogniat; Moe H Aung; Ranjay Chakraborty; Jeffrey H Boatright; Machelle T Pardue
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-10       Impact factor: 4.799

10.  Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.

Authors:  Mark A Kanow; Michelle M Giarmarco; Connor Sr Jankowski; Kristine Tsantilas; Abbi L Engel; Jianhai Du; Jonathan D Linton; Christopher C Farnsworth; Stephanie R Sloat; Austin Rountree; Ian R Sweet; Ken J Lindsay; Edward D Parker; Susan E Brockerhoff; Martin Sadilek; Jennifer R Chao; James B Hurley
Journal:  Elife       Date:  2017-09-13       Impact factor: 8.140
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  7 in total

1.  Glucose uptake by GLUT1 in photoreceptors is essential for outer segment renewal and rod photoreceptor survival.

Authors:  Lauren L Daniele; John Y S Han; Ivy S Samuels; Ravikiran Komirisetty; Nikhil Mehta; Jessica L McCord; Minzhong Yu; Yekai Wang; Kathleen Boesze-Battaglia; Brent A Bell; Jianhai Du; Neal S Peachey; Nancy J Philp
Journal:  FASEB J       Date:  2022-08       Impact factor: 5.834

Review 2.  The Neuroprotective Role of Retbindin, a Metabolic Regulator in the Neural Retina.

Authors:  Xue Zhao; Lars Tebbe; Muna I Naash; Muayyad R Al-Ubaidi
Journal:  Front Pharmacol       Date:  2022-07-06       Impact factor: 5.988

3.  Late-stage rescue of visually guided behavior in the context of a significantly remodeled retinitis pigmentosa mouse model.

Authors:  Jacqueline Kajtna; Stephen H Tsang; Susanne F Koch
Journal:  Cell Mol Life Sci       Date:  2022-02-23       Impact factor: 9.207

Review 4.  Metabolism and Vascular Retinopathies: Current Perspectives and Future Directions.

Authors:  Charandeep Singh
Journal:  Diagnostics (Basel)       Date:  2022-04-05

5.  Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration.

Authors:  Akanksha Roy; Arianna Tolone; Riet Hilhorst; John Groten; Tushar Tomar; François Paquet-Durand
Journal:  Cell Death Discov       Date:  2022-03-03

6.  Aster proteins mediate carotenoid transport in mammalian cells.

Authors:  Sepalika Bandara; Srinivasagan Ramkumar; Sanae Imanishi; Linda D Thomas; Onkar B Sawant; Yoshikazu Imanishi; Johannes von Lintig
Journal:  Proc Natl Acad Sci U S A       Date:  2022-04-08       Impact factor: 12.779

7.  DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.

Authors:  Jiyang Cai; Christopher Litwin; Rui Cheng; Jian-Xing Ma; Yan Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-08       Impact factor: 12.779
  7 in total

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