Yanyan Bai1,2, Hongsheng Sun3,4, Naiwen Hu5,6, Dongxia Liu5,6, Na Zhao5,6, Xia Wang5,6. 1. Department of Rheumatology and Immunology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. 714466429@qq.com. 2. Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China. 714466429@qq.com. 3. Department of Rheumatology and Immunology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. 229264076@qq.com. 4. Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China. 229264076@qq.com. 5. Department of Rheumatology and Immunology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. 6. Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
Abstract
OBJECTIVE: Human leukocyte antigen (HLA)-B27 plays a crucial role in the pathogenesis of AS. TNF polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF polymorphism is associated with AS susceptibility in HLA-27-positive population. METHODS: Our search was done in the Pubmed, Embase, and Cochrane databases (up to March 2020). The pooled and individual odds ratios (ORs) with 95% confidence intervals (CIs) of the minor allele of each locus were presented to assess the associations between TNF polymorphisms and AS in HLA-B27-positive population. RESULTS: Ten studies from 8 articles were included in this meta-analysis. In the population of HLA-B27-positive patients and random healthy controls, there were statistical significance in the evaluation of association between the minor allele of TNF-238, -308, -857, -1031 and -863 and AS susceptibility, respectively. In the population of HLA-B27-positive patients and HLA-B27-positive healthy controls, there were no statistical differences in the comparison of minor allele of with their respective major allele in the fixed model. CONCLUSIONS: There was no association of the TNF polymorphisms with AS in the HLA-B27-positive AS group and HLA-B27-positive control group. Polymorphisms of TNF-238, -308, -857, -1031, -863 were associated with AS susceptibility in the HLA-B27-positive AS patients and random control population. Other gene SNPs except TNF may play an important role in AS susceptibility in HLA-B27-positive population.
OBJECTIVE:Human leukocyte antigen (HLA)-B27 plays a crucial role in the pathogenesis of AS. TNF polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF polymorphism is associated with AS susceptibility in HLA-27-positive population. METHODS: Our search was done in the Pubmed, Embase, and Cochrane databases (up to March 2020). The pooled and individual odds ratios (ORs) with 95% confidence intervals (CIs) of the minor allele of each locus were presented to assess the associations between TNF polymorphisms and AS in HLA-B27-positive population. RESULTS: Ten studies from 8 articles were included in this meta-analysis. In the population of HLA-B27-positive patients and random healthy controls, there were statistical significance in the evaluation of association between the minor allele of TNF-238, -308, -857, -1031 and -863 and AS susceptibility, respectively. In the population of HLA-B27-positive patients and HLA-B27-positive healthy controls, there were no statistical differences in the comparison of minor allele of with their respective major allele in the fixed model. CONCLUSIONS: There was no association of the TNF polymorphisms with AS in the HLA-B27-positive AS group and HLA-B27-positive control group. Polymorphisms of TNF-238, -308, -857, -1031, -863 were associated with AS susceptibility in the HLA-B27-positive ASpatients and random control population. Other gene SNPs except TNF may play an important role in AS susceptibility in HLA-B27-positive population.
Authors: A Milicic; F Lindheimer; S Laval; M Rudwaleit; H Ackerman; P Wordsworth; T Hohler; M A Brown Journal: Genes Immun Date: 2000-10 Impact factor: 2.676
Authors: Elsa Sousa; Joana Caetano-Lopes; Patrícia Pinto; Fernando Pimentel; José Teles; Helena Canhão; Ana Rodrigues; Catarina Resende; Ana Filipa Mourão; Célia Ribeiro; Teresa Laura Pinto; Carlos Miranda Rosa; José Alberto Pereira da Silva; Jaime Branco; Francisco Ventura; Mário Viana Queiroz; João Eurico Fonseca Journal: Ann N Y Acad Sci Date: 2009-09 Impact factor: 5.691
Authors: E L Kaijzel; B M Brinkman; M V van Krugten; L Smith; T W Huizinga; G M Verjans; F C Breedveld; C L Verweij Journal: Hum Immunol Date: 1999-02 Impact factor: 2.850