Literature DB >> 3410052

Differential down-regulation of protein kinase C subspecies in KM3 cells.

K Ase1, N Berry, U Kikkawa, A Kishimoto, Y Nishizuka.   

Abstract

The down-regulation of protein kinase C (PKC) subspecies in KM3 cells (a pre-B, pre-T cell line) has been examined. The PKC from KM3 cells was resolved into two subspecies, type II (mainly beta II) and type III (alpha), upon hydroxyapatite column chromatography. Biochemical and immunocytochemical analysis revealed that, when these cells were treated with 12-O-tetradecanoylphorbol 13-acetate (TPA), the time course of down-regulation of the PKC subspecies was different; type II PKC was translocated and depleted from the cell more quickly than type III enzyme. The results suggest that each PKC subspecies plays a different role in the cellular response to TPA and probably to other external stimuli.

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Year:  1988        PMID： 3410052     DOI： 10.1016/0014-5793(88)80064-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.

Authors:  A Ito; N Saito; M Hirata; A Kose; T Tsujino; C Yoshihara; K Ogita; A Kishimoto; Y Nishizuka; C Tanaka
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

2.  Effects of phorbol ester on cholecystokinin octapeptide-evoked exocrine pancreatic secretion in the rat.

Authors:  L P Francis; P J Camello; J Singh; G M Salido; J A Madrid
Journal:  J Physiol       Date:  1990-12       Impact factor: 5.182

3.  Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils.

Authors:  S Pontremoli; M Michetti; E Melloni; B Sparatore; F Salamino; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

4.  Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death.

Authors:  M Favaron; H Manev; R Siman; M Bertolino; A M Szekely; G DeErausquin; A Guidotti; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

5.  Differential down-regulation of protein kinase C selectively affects IgE-dependent exocytosis and inositol trisphosphate formation.

Authors:  G Gat-Yablonski; R Sagi-Eisenberg
Journal:  Biochem J       Date:  1990-09-15       Impact factor: 3.857

6.  The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.

Authors:  H Greif; J Ben-Chaim; T Shimon; E Bechor; H Eldar; E Livneh
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

7.  Acid activation of immediate early genes in renal epithelial cells.

Authors:  Y Yamaji; O W Moe; R T Miller; R J Alpern
Journal:  J Clin Invest       Date:  1994-09       Impact factor: 14.808

8.  Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription.

Authors:  T Shioda; T Ohta; K J Isselbacher; D B Rhoads
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205

9.  Possible regulatory functions of protein kinase C-alpha and -epsilon isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis.

Authors:  A Huwiler; D Fabbro; J Pfeilschifter
Journal:  Biochem J       Date:  1991-10-15       Impact factor: 3.857

10.  Agonist-mediated tissue factor expression in cultured vascular smooth muscle cells. Role of Ca2+ mobilization and protein kinase C activation.

Authors:  M B Taubman; J D Marmur; C L Rosenfield; A Guha; S Nichtberger; Y Nemerson
Journal:  J Clin Invest       Date:  1993-02       Impact factor: 14.808
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