Literature DB >> 3410047

Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA.

D Earnshaw1, J W Dale, P S Goldfarb, G G Gibson.   

Abstract

The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801-810] apart from the presence of an additional 75 nucleotides inserted adjacent to the 3'-end of the coding region. Northern blot analysis indicates that this is probably a consequence of differential splicing, which may be relevant to the tissue-specific regulation of this gene.

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Year:  1988        PMID: 3410047     DOI: 10.1016/0014-5793(88)80055-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  7 in total

1.  A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.

Authors:  Y M Heng; C S Kuo; P S Jones; R Savory; R M Schulz; S R Tomlinson; T J Gray; D R Bell
Journal:  Biochem J       Date:  1997-08-01       Impact factor: 3.857

2.  Comparative induction of cytochrome P450IVA1 and peroxisome proliferation by ciprofibrate in the rat and marmoset.

Authors:  J M Makowska; F W Bonner; G G Gibson
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

3.  Localization and differential induction of cytochrome P450IVA and acyl-CoA oxidase in rat liver.

Authors:  D R Bell; R G Bars; G G Gibson; C R Elcombe
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

4.  Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.

Authors:  D R Bell; N J Plant; C G Rider; L Na; S Brown; I Ateitalla; S K Acharya; M H Davies; E Elias; N A Jenkins
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

5.  High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein.

Authors:  C W Fisher; M S Shet; D L Caudle; C A Martin-Wixtrom; R W Estabrook
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

6.  Testosterone-mediated regulation of mouse renal cytochrome P-450 isoenzymes.

Authors:  C J Henderson; A R Scott; C S Yang; C R Wolf
Journal:  Biochem J       Date:  1990-03-15       Impact factor: 3.857

7.  Rat DARPP-32: cloning, sequencing, and characterization of the cDNA.

Authors:  M E Ehrlich; T Kurihara; P Greengard
Journal:  J Mol Neurosci       Date:  1990       Impact factor: 3.444

  7 in total

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