Literature DB >> 34099808

SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions.

Luis Fernando Saraiva Macedo Timmers1,2, Julia Vasconcellos Peixoto3, Rodrigo Gay Ducati4, José Fernando Ruggiero Bachega5, Leandro de Mattos Pereira6, Rafael Andrade Caceres5,7,8, Fernanda Majolo4, Guilherme Liberato da Silva9, Débora Bublitz Anton4, Odir Antônio Dellagostin10, João Antônio Pegas Henriques4,11, Léder Leal Xavier12, Márcia Inês Goettert4,11, Stefan Laufer13.   

Abstract

Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, contributing towards studies of selective structure-based drug discovery and vaccine development.

Entities:  

Year:  2021        PMID： 34099808     DOI： 10.1038/s41598-021-91585-6

Source DB:  PubMed          Journal:  Sci Rep        ISSN： 2045-2322            Impact factor:   4.379


  55 in total

1.  The median age of primary malaria infection in an Amazonian community: probit analysis of cross-sectional data.

Authors:  M U Ferreira; L M Camargo; C S Ferreira
Journal:  Acta Trop       Date:  1994-10       Impact factor: 3.112

2.  [Effects of noise and vibration during embryogenesis on fetal development and postnatal growth of the mouse].

Authors:  V Briese; J Fanghänel; A Briese; H Gasow
Journal:  Zentralbl Gynakol       Date:  1982

3.  Clinical and cytogenetic spectrum of duplication 3p.

Authors:  S Braga; A Schmidt
Journal:  Eur J Pediatr       Date:  1982-03       Impact factor: 3.183

4.  [Epidemiology of hypothyroidism due to congenital malformation of the gland: athyreosis or ectopic thyroid (author's transl)].

Authors:  J Goujard; A Safar; A Rolland; J C Job
Journal:  Arch Fr Pediatr       Date:  1981-12

5.  Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission.

Authors:  Sayantan Laha; Joyeeta Chakraborty; Shantanab Das; Soumen Kanti Manna; Sampa Biswas; Raghunath Chatterjee
Journal:  Infect Genet Evol       Date:  2020-06-30       Impact factor: 3.342

6.  Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.

Authors:  Roujian Lu; Xiang Zhao; Juan Li; Peihua Niu; Bo Yang; Honglong Wu; Wenling Wang; Hao Song; Baoying Huang; Na Zhu; Yuhai Bi; Xuejun Ma; Faxian Zhan; Liang Wang; Tao Hu; Hong Zhou; Zhenhong Hu; Weimin Zhou; Li Zhao; Jing Chen; Yao Meng; Ji Wang; Yang Lin; Jianying Yuan; Zhihao Xie; Jinmin Ma; William J Liu; Dayan Wang; Wenbo Xu; Edward C Holmes; George F Gao; Guizhen Wu; Weijun Chen; Weifeng Shi; Wenjie Tan
Journal:  Lancet       Date:  2020-01-30       Impact factor: 79.321

7.  Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2.

Authors:  Qihui Wang; Yanfang Zhang; Lili Wu; Sheng Niu; Chunli Song; Zengyuan Zhang; Guangwen Lu; Chengpeng Qiao; Yu Hu; Kwok-Yung Yuen; Qisheng Wang; Huan Zhou; Jinghua Yan; Jianxun Qi
Journal:  Cell       Date:  2020-04-09       Impact factor: 41.582

8.  A unique view of SARS-CoV-2 through the lens of ORF8 protein.

Authors:  Sk Sarif Hassan; Alaa A A Aljabali; Pritam Kumar Panda; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Amos Lal; Gajendra Kumar Azad; Vladimir N Uversky; Samendra P Sherchan; Wagner Baetas-da-Cruz; Bruce D Uhal; Nima Rezaei; Gaurav Chauhan; Debmalya Barh; Elrashdy M Redwan; Guy W Dayhoff; Nicolas G Bazan; Ángel Serrano-Aroca; Amr El-Demerdash; Yogendra K Mishra; Giorgio Palu; Kazuo Takayama; Adam M Brufsky; Murtaza M Tambuwala
Journal:  Comput Biol Med       Date:  2021-04-15       Impact factor: 6.698

9.  Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.

Authors:  Sk Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N Uversky; Alaa A A Aljabali; Kenneth Lundstrom; Bruce D Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M Brufsky
Journal:  Int J Biol Macromol       Date:  2021-04-16       Impact factor: 6.953

10.  Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.

Authors:  Xiuyuan Ou; Yan Liu; Xiaobo Lei; Pei Li; Dan Mi; Lili Ren; Li Guo; Ruixuan Guo; Ting Chen; Jiaxin Hu; Zichun Xiang; Zhixia Mu; Xing Chen; Jieyong Chen; Keping Hu; Qi Jin; Jianwei Wang; Zhaohui Qian
Journal:  Nat Commun       Date:  2020-03-27       Impact factor: 14.919
View more
  7 in total

1.  Detecting lineage-defining mutations in SARS-CoV-2 using colorimetric RT-LAMP without probes or additional primers.

Authors:  Carlos Abelardo Dos Santos; Lívia do Carmo Silva; Marcio Neres de Souza Júnior; Geovana de Melo Mendes; Paulo Felipe Neves Estrela; Kézia Gomes de Oliveira; Juliana Santana de Curcio; Paola Cristina Resende; Marilda Mendonça Siqueira; Alex Pauvolid-Corrêa; Gabriela Rodrigues Mendes Duarte; Elisângela de Paula Silveira-Lacerda
Journal:  Sci Rep       Date:  2022-07-07       Impact factor: 4.996

2.  Spike Mutation Profiles Associated With SARS-CoV-2 Breakthrough Infections in Delta Emerging and Predominant Time Periods in British Columbia, Canada.

Authors:  Chad D Fibke; Yayuk Joffres; John R Tyson; Caroline Colijn; Naveed Z Janjua; Chris Fjell; Natalie Prystajecky; Agatha Jassem; Hind Sbihi
Journal:  Front Public Health       Date:  2022-07-04

Review 3.  Development of synthetic antigen vaccines for COVID-19.

Authors:  Maria da Conceição Viana Invenção; Alanne Rayssa da Silva Melo; Larissa Silva de Macêdo; Thaís Souto Paula da Costa Neves; Cristiane Moutinho Lagos de Melo; Marcelo Nazário Cordeiro; Marcus Vinicius de Aragão Batista; Antonio Carlos de Freitas
Journal:  Hum Vaccin Immunother       Date:  2021-10-06       Impact factor: 3.452

4.  Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs.

Authors:  Stephanie Seneff; Greg Nigh; Anthony M Kyriakopoulos; Peter A McCullough
Journal:  Food Chem Toxicol       Date:  2022-04-15       Impact factor: 5.572

5.  A Preliminary Genomic Analysis of the Omicron Variants of SARS-CoV-2 in Central India During the third wave of the COVID-19 Pandemic.

Authors:  Priyanka Singh; Sanjay Singh Negi; Anudita Bhargava; Vara Prasad Kolla; Ripu Daman Arora
Journal:  Arch Med Res       Date:  2022-08-23       Impact factor: 8.323

Review 6.  Covid-19 Outbreak in Brazil: Health, Social, Political, and Economic Implications.

Authors:  Michele Kremer Sott; Mariluza Sott Bender; Kamila da Silva Baum
Journal:  Int J Health Serv       Date:  2022-09-04       Impact factor: 1.851

7.  SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic.

Authors:  Wael H Roshdy; Mohamed K Khalifa; James Emmanuel San; Houriiyah Tegally; Eduan Wilkinson; Shymaa Showky; Darren Patrick Martin; Monika Moir; Amel Naguib; Nancy Elguindy; Mokhtar R Gomaa; Manal Fahim; Hanaa Abu Elsood; Amira Mohsen; Ramy Galal; Mohamed Hassany; Richard J Lessells; Ahmed A Al-Karmalawy; Rabeh El-Shesheny; Ahmed M Kandeil; Mohamed A Ali; Tulio de Oliveira
Journal:  Viruses       Date:  2022-08-25       Impact factor: 5.818
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.