| Literature DB >> 34099645 |
Ayana T Ruffin1,2,3,4, Anthony R Cillo1,2,4, Tracy Tabib5, Angen Liu6, Sayali Onkar1,2,3,4, Sheryl R Kunning1,2,4, Caleb Lampenfeld1,2,4, Huda I Atiya4,7, Irina Abecassis1,2,4, Cornelius H L Kürten8, Zengbiao Qi5, Ryan Soose6, Umamaheswar Duvvuri4,5, Seungwon Kim6, Steffi Oesterrich4,9,10, Robert Lafyatis5,6, Lan G Coffman4,7, Robert L Ferris1,2,4,6,11, Dario A A Vignali1,2,4,11, Tullia C Bruno12,13,14,15.
Abstract
Current immunotherapy paradigms aim to reinvigorate CD8+ T cells, but the contribution of humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in head and neck squamous cell carcinoma (HNSCC) caused by human papillomavirus infection (HPV+), patients have transcriptional signatures of germinal center (GC) tumor infiltrating B cells (TIL-Bs) and spatial organization of immune cells consistent with tertiary lymphoid structures (TLS) with GCs, both of which correlate with favorable outcome. GC TIL-Bs in HPV+ HNSCC are characterized by distinct waves of gene expression consistent with dark zone, light zone and a transitional state of GC B cells. Semaphorin 4a expression is enhanced on GC TIL-Bs present in TLS of HPV+ HNSCC and during the differentiation of TIL-Bs. Our study suggests that therapeutics to enhance TIL-B responses in HNSCC should be prioritized in future studies to determine if they can complement current T cell mediated immunotherapies.Entities:
Year: 2021 PMID： 34099645 DOI： 10.1038/s41467-021-23355-x
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919