Literature DB >> 3409964

Specific motor effects of capsaicin on human jejunum.

C A Maggi1, R Patacchini, P Santicioli, S Giuliani, D Turini, G Barbanti, P Beneforti, D Misuri, A Meli.   

Abstract

Capsaicin (1 microM) produced a biphasic effect on the motility of longitudinal muscle strips from human jejunum e.g. an initial inhibitory effect on nerve-mediated contractions followed by a delayed increase in motility. Neither effect was observed upon a second application of the drug, indicating desensitization, a proposed marker of the action of capsaicin on sensory nerves. Both substance P and neurokinin A produced a contraction of isolated human jejunum, while calcitonin gene-related peptide had a small and inconsistent inhibitory effect.

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Year:  1988        PMID： 3409964     DOI： 10.1016/0014-2999(88)90676-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Intraluminal capsaicin does not affect fluid and electrolyte absorption in the human jejunum but does cause pain.

Authors:  J Hammer; H F Hammer; A J Eherer; W Petritsch; P Holzer; G J Krejs
Journal:  Gut       Date:  1998-08       Impact factor: 23.059

2.  Motor response of the human isolated small intestine and urinary bladder to porcine neuromedin U-8.

Authors:  C A Maggi; R Patacchini; S Giuliani; D Turini; G Barbanti; P Rovero; A Meli
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

3.  Human isolated small intestine: motor responses of the longitudinal muscle to field stimulation and exogenous neuropeptides.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani; D Turini; G Barbanti; P Beneforti; D Misuri; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-04       Impact factor: 3.000

4.  Human isolated ileum: motor responses of the circular muscle to electrical field stimulation and exogenous neuropeptides.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani; D Turini; G Barbanti; A Giachetti; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-03       Impact factor: 3.000

5.  The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide.

Authors:  L Bartho; P Holzer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

6.  Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit.

Authors:  A Bouraoui; J L Brazier; H Zouaghi; M Rousseau
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1995 Jul-Sep       Impact factor: 2.441

7.  Chemical nociception in the jejunum induced by capsaicin.

Authors:  B Schmidt; J Hammer; P Holzer; H F Hammer
Journal:  Gut       Date:  2004-08       Impact factor: 23.059
  7 in total

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