Literature DB >> 34097477

Comparison of the Acinetobacter baumannii Reference Strains ATCC 17978 and ATCC 19606 in Antimicrobial Resistance Mediated by the AdeABC Efflux Pump.

K Lucaßen1, S Gerson1, K Xanthopoulou1,2, J Wille1,2, T Wille1, H Seifert1,2, P G Higgins1,2.   

Abstract

The Acinetobacter baumannii RND efflux pump AdeABC is regulated by the 2-component regulator AdeRS. In this study, we compared the regulation and expression of AdeABC of the reference strains ATCC 17978 and ATCC 19606. A clearly stronger efflux activity was demonstrated for ATCC 19606. An amino acid substitution at residue 172 of adeS was identified as a potential cause for differential expression of the pump. Therefore, we recommend caution with exclusively using single reference strains for research.

Entities:  

Keywords:  Acinetobacter; antibiotic resistance; cloning; efflux pumps

Mesh：

Substances：

Year:  2021        PMID： 34097477      PMCID： PMC8284471          DOI： 10.1128/AAC.00570-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

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3.  Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains.

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4.  Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii.

Authors:  Inga V Leus; Jon W Weeks; Vincent Bonifay; Lauren Smith; Sophie Richardson; Helen I Zgurskaya
Journal:  J Bacteriol       Date:  2018-06-11       Impact factor: 3.490

5.  Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system.

Authors:  Isabelle Marchand; Laurence Damier-Piolle; Patrice Courvalin; Thierry Lambert
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

Review 6.  Acinetobacter baumannii: emergence of a successful pathogen.

Authors:  Anton Y Peleg; Harald Seifert; David L Paterson
Journal:  Clin Microbiol Rev       Date:  2008-07       Impact factor: 26.132

Review 7.  Exploring the proteomic characteristics of the Escherichia coli B and K-12 strains in different cellular compartments.

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8.  AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex.

Authors:  Alexey Ruzin; David Keeney; Patricia A Bradford
Journal:  J Antimicrob Chemother       Date:  2007-03-15       Impact factor: 5.790

9.  Predicting the functional effect of amino acid substitutions and indels.

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10.  Acinetobacter baumannii Virulence Is Mediated by the Concerted Action of Three Phospholipases D.

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  1 in total

1.  Characterization of Amino Acid Substitutions in the Two-Component Regulatory System AdeRS Identified in Multidrug-Resistant Acinetobacter baumannii.

Authors:  K Lucaßen; K Xanthopoulou; J Wille; T Wille; Y Wen; X Hua; H Seifert; P G Higgins
Journal:  mSphere       Date:  2021-11-24       Impact factor: 4.389
  1 in total

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