| Literature DB >> 3409582 |
Y Yamazaki1, S Oida, Y Akimoto, S Shioda.
Abstract
A composite consisting of 1 mg of bone morphogenetic protein (BMP) and 5 mg of plaster of Paris (PLP) was implanted into the mouse femoral muscle. Control PLP without BMP was implanted into the contralateral muscle. The BMP/PLP composite induced cartilage formation within two weeks, trabecular bone within three weeks, and lamellar bone including bone marrow within six weeks. PLP did not disturb BMP-induced bone formation. In addition, the BMP/PLP composite was resorbed early after implantation. These results suggest that PLP composite system is one of the most suitable BMP delivery systems currently available.Entities:
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Year: 1988 PMID: 3409582
Source DB: PubMed Journal: Clin Orthop Relat Res ISSN: 0009-921X Impact factor: 4.176