| Literature DB >> 34091499 |
Michael D Tarpey1, Adam J Amorese1, Elizabeth R LaFave2, Everett C Minchew1, Kelsey H Fisher-Wellman, Joseph M McClung, Eli G Hvastkovs2, Espen E Spangenburg.
Abstract
Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus. Here, we propose BRCA1 expression is critical for the maintenance of force production and mitochondrial respiration in skeletal muscle.Entities:
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Year: 2021 PMID： 34091499 PMCID： PMC8495729 DOI： 10.1249/JES.0000000000000265
Source DB: PubMed Journal: Exerc Sport Sci Rev ISSN： 0091-6331 Impact factor: 6.642