Jessica K Nadalin1, Uri T Eden2, Xue Han3, R Mark Richardson4, Catherine J Chu5, Mark A Kramer6. 1. Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States. 2. Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States; Center for Systems Neuroscience, Boston University, Boston, MA 02215, United States. 3. Center for Systems Neuroscience, Boston University, Boston, MA 02215, United States; Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States. 4. Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, United States. 5. Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States. 6. Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States; Center for Systems Neuroscience, Boston University, Boston, MA 02215, United States. Electronic address: mak@bu.edu.
Abstract
BACKGROUND: A reliable biomarker to identify cortical tissue responsible for generating epileptic seizures is required to guide prognosis and treatment in epilepsy. Combined spike ripple events are a promising biomarker for epileptogenic tissue that currently require expert review for accurate identification. This expert review is time consuming and subjective, limiting reproducibility and high-throughput applications. NEW METHOD: To address this limitation, we develop a fully-automated method for spike ripple detection. The method consists of a convolutional neural network trained to compute the probability that a spectrogram image contains a spike ripple. RESULTS: We validate the proposed spike ripple detector on expert-labeled data and show that this detector accurately separates subjects with low and high seizure risks. COMPARISON WITH EXISTING METHOD: The proposed method performs as well as existing methods that require manual validation of candidate spike ripple events. The introduction of a fully automated method reduces subjectivity and increases rigor and reproducibility of this epilepsy biomarker. CONCLUSION: We introduce and validate a fully-automated spike ripple detector to support utilization of this epilepsy biomarker in clinical and translational work.
BACKGROUND: A reliable biomarker to identify cortical tissue responsible for generating epileptic seizures is required to guide prognosis and treatment in epilepsy. Combined spike ripple events are a promising biomarker for epileptogenic tissue that currently require expert review for accurate identification. This expert review is time consuming and subjective, limiting reproducibility and high-throughput applications. NEW METHOD: To address this limitation, we develop a fully-automated method for spike ripple detection. The method consists of a convolutional neural network trained to compute the probability that a spectrogram image contains a spike ripple. RESULTS: We validate the proposed spike ripple detector on expert-labeled data and show that this detector accurately separates subjects with low and high seizure risks. COMPARISON WITH EXISTING METHOD: The proposed method performs as well as existing methods that require manual validation of candidate spike ripple events. The introduction of a fully automated method reduces subjectivity and increases rigor and reproducibility of this epilepsy biomarker. CONCLUSION: We introduce and validate a fully-automated spike ripple detector to support utilization of this epilepsy biomarker in clinical and translational work.
Authors: Michal T Kucewicz; Jan Cimbalnik; Joseph Y Matsumoto; Benjamin H Brinkmann; Mark R Bower; Vincent Vasoli; Vlastimil Sulc; Fred Meyer; W R Marsh; S M Stead; Gregory A Worrell Journal: Brain Date: 2014-06-11 Impact factor: 13.501