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Literature DB >> 340907

Properties of ribosomes from erythromycin resistant mutants of Escherichia coli.

Abstract

We have studied the in vitro properties of ribosomes from several mutants resistant to erythromycin. Mutations in three different genes may confer resistance to erythromycin. Two of them are structural genes for proteins L4 and L22 of the large subunit. The third mutation (in eryC gene) seems to affect mainly the small subunit. The mechanism of action of the antibiotic may involve both subunits.

Entities: Chemical Species

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Year: 1977 PMID： 340907 DOI： 10.1007/bf00267181

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

13 in total

1. Ribosomal subunit interaction as studied by light scattering. Evidence of different classes of ribosome preparations.

Authors: P Debey; G Hui Bon Hoa; P Douzou; T Godefroy-Colburn; M Graffe; M Grunberg-Manago
Journal: Biochemistry Date: 1975-04-22 Impact factor: 3.162

Review 2. Recalibrated linkage map of Escherichia coli K-12.

Authors: B J Bachmann; K B Low; A L Taylor
Journal: Bacteriol Rev Date: 1976-03

3. A new ribosomal mutation which affects the two ribosomal subunits in Escherichia coli.

Authors: D Pardo; R Rosset
Journal: Mol Gen Genet Date: 1977-06-08

4. Genetic studies of erythromycin resistant mutants of Escherichia coli.

Authors: D Pardo; R Rosset
Journal: Mol Gen Genet Date: 1974

5. Ribosomes from erythromycin-resistant mutants of Escherichia coli Q13.

Authors: E Otaka; H Teraoka; M Tamaki; K Tanaka; S Osawa
Journal: J Mol Biol Date: 1970-03 Impact factor: 5.469

6. Two types of binding of erythromycin to ribosomes from antibiotic-sensitive and -resistant Bacillus subtilis 168.

Authors: N L Oleinick; J W Corcoran
Journal: J Biol Chem Date: 1969-02-25 Impact factor: 5.157

7. The ribosomal proteins of Escherichia coli. I. Purification of the 30S ribosomal proteins.

Authors: S J Hardy; C G Kurland; P Voynow; G Mora
Journal: Biochemistry Date: 1969-07 Impact factor: 3.162

8. The requirements for specific sRNA binding by ribosomes.

Authors: C G Kurland
Journal: J Mol Biol Date: 1966-06 Impact factor: 5.469

9. Binding of erythromycin to the 50S ribosomal subunit is affected by alterations in the 30S ribosomal subunit.

Authors: L Saltzman; D Apirion
Journal: Mol Gen Genet Date: 1976-02-02

10. Binding of [14C]erythromycin to Escherichia coli ribosomes.

Authors: S Pestka
Journal: Antimicrob Agents Chemother Date: 1974-10 Impact factor: 5.191

19 in total

1. Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae.

Authors: F Depardieu; P Courvalin
Journal: Antimicrob Agents Chemother Date: 2001-01 Impact factor: 5.191

Review 2. Macrolide resistance conferred by base substitutions in 23S rRNA.

Authors: B Vester; S Douthwaite
Journal: Antimicrob Agents Chemother Date: 2001-01 Impact factor: 5.191

3. Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnel.

Authors: Marlon G Lawrence; Lasse Lindahl; Janice M Zengel
Journal: J Bacteriol Date: 2008-06-27 Impact factor: 3.490

4. Increased kasugamycin sensitivity in Escherichia coli caused by the presence of an inducible erythromycin resistance (erm) gene of Streptococcus pyogenes.

Authors: A N Suvorov; B van Gemen; P H van Knippenberg
Journal: Mol Gen Genet Date: 1988-12

5. Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.

Authors: Benoit Desmolaize; Simon Rose; Cornelia Wilhelm; Ralf Warrass; Stephen Douthwaite
Journal: Antimicrob Agents Chemother Date: 2011-06-27 Impact factor: 5.191