Literature DB >> 34087176

The BAFfling story of MN1-induced leukemogenesis.

Aaron J Stonestrom1, Ross L Levine2.   

Abstract

Riedel et al. (2021) show that expression of MN1 is capable of blocking myeloid differentiation and initiating leukemia through mechanisms that require Brg1-containing chromatin remodeling complexes. Intriguingly, this process depends on an unstructured polyglutamine repeat region within MN1.
Copyright © 2021 Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34087176      PMCID： PMC9278559          DOI： 10.1016/j.molcel.2021.05.001

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   19.328


  11 in total

1.  MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice.

Authors:  C Carella; J Bonten; J Rehg; G C Grosveld
Journal:  Leukemia       Date:  2006-06-29       Impact factor: 11.528

Review 2.  The emerging complexity of gene fusions in cancer.

Authors:  Fredrik Mertens; Bertil Johansson; Thoas Fioretos; Felix Mitelman
Journal:  Nat Rev Cancer       Date:  2015-06       Impact factor: 60.716

3.  High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics.

Authors:  Michael Heuser; Gernot Beutel; Juergen Krauter; Konstanze Döhner; Nils von Neuhoff; Brigitte Schlegelberger; Arnold Ganser
Journal:  Blood       Date:  2006-08-15       Impact factor: 22.113

4.  Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain.

Authors:  Gaylor Boulay; Gabriel J Sandoval; Nicolo Riggi; Sowmya Iyer; Rémi Buisson; Beverly Naigles; Mary E Awad; Shruthi Rengarajan; Angela Volorio; Matthew J McBride; Liliane C Broye; Lee Zou; Ivan Stamenkovic; Cigall Kadoch; Miguel N Rivera
Journal:  Cell       Date:  2017-08-24       Impact factor: 41.582

5.  Evidence for additive and synergistic action of mammalian enhancers during cell fate determination.

Authors:  Jinmi Choi; Kseniia Lysakovskaia; Gregoire Stik; Carina Demel; Johannes Söding; Tian V Tian; Thomas Graf; Patrick Cramer
Journal:  Elife       Date:  2021-03-26       Impact factor: 8.140

6.  Selective inhibition of tumor oncogenes by disruption of super-enhancers.

Authors:  Jakob Lovén; Heather A Hoke; Charles Y Lin; Ashley Lau; David A Orlando; Christopher R Vakoc; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

7.  Ectopia associated MN1 fusions and aberrant activation in myeloid neoplasms with t(12;22)(p13;q12).

Authors:  Tong Wang; Xue Chen; Shuang Hui; Jingbo Ni; Ying Yin; Wei Cao; Yan Zhang; Xinyu Wang; Xiaoli Ma; Panxiang Cao; Mingyue Liu; Kylan N Chen; Fang Wang; Yang Zhang; Daijing Nie; Lili Yuan; Hongxing Liu
Journal:  Cancer Gene Ther       Date:  2020-01-06       Impact factor: 5.987

8.  Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.

Authors:  Simone S Riedel; Congcong Lu; Hongbo M Xie; Kevin Nestler; Marit W Vermunt; Alexandra Lenard; Laura Bennett; Nancy A Speck; Ichiro Hanamura; Julie A Lessard; Gerd A Blobel; Benjamin A Garcia; Kathrin M Bernt
Journal:  Mol Cell       Date:  2021-05-10       Impact factor: 19.328

9.  Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.

Authors:  Courteney K Lai; Yeonsook Moon; Florian Kuchenbauer; Daniel T Starzcynowski; Bob Argiropoulos; Eric Yung; Philip Beer; Adrian Schwarzer; Amit Sharma; Gyeongsin Park; Malina Leung; Grace Lin; Sarah Vollett; Stephen Fung; Connie J Eaves; Aly Karsan; Andrew P Weng; R Keith Humphries; Michael Heuser
Journal:  PLoS One       Date:  2014-11-17       Impact factor: 3.240

10.  Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Authors:  Junwei Shi; Warren A Whyte; Cinthya J Zepeda-Mendoza; Joseph P Milazzo; Chen Shen; Jae-Seok Roe; Jessica L Minder; Fatih Mercan; Eric Wang; Melanie A Eckersley-Maslin; Amy E Campbell; Shinpei Kawaoka; Sarah Shareef; Zhu Zhu; Jude Kendall; Matthias Muhar; Christian Haslinger; Ming Yu; Robert G Roeder; Michael H Wigler; Gerd A Blobel; Johannes Zuber; David L Spector; Richard A Young; Christopher R Vakoc
Journal:  Genes Dev       Date:  2013-11-27       Impact factor: 11.361
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