Jian Yu1,2,3,4, Yongheng Huang1,2,3,4,5, Lei Zhou6, Jingzi ZhangBao6, Yuan Zong1,2,3,4, Chao Quan7, Min Wang8,9,10,11. 1. Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. 2. NHC Key Laboratory of Myopia, Fudan University, Shanghai, China. 3. Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China. 4. Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. 5. Department of Ophthalmology, Kiang Wu Hospital, Macau Special Administration Region, People's Republic of China. 6. Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China. 7. Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China. chao_quan@fudan.edu.cn. 8. Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. wangmin83@yahoo.com. 9. NHC Key Laboratory of Myopia, Fudan University, Shanghai, China. wangmin83@yahoo.com. 10. Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China. wangmin83@yahoo.com. 11. Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. wangmin83@yahoo.com.
Abstract
OBJECTIVE: To compare the retinal vascular network and structure of optic neuritis associated with myelin oligodendrocyte glycoprotein antibodies (MOG-ON) or aquaporin-4 antibodies (AQP4-ON). METHODS: Nineteen patients with MOG-ON (29 eyes), 24 patients with AQP4-ON (43 eyes), and 25 healthy participants (50 eyes) were enrolled. The best-corrected visual acuity (BCVA), mean deviation (MD), retinal nerve fiber layer (RNFL) thickness, parafoveal ganglion cell and inner plexiform layer (GCIPL) thickness, and vessel densities in the peripapillary and parafoveal areas were measured. RESULTS: The BCVA, RNFL thickness, GCIPL thickness, and vessel densities in the peripapillary and parafoveal areas were significantly decreased in the AQP4-ON and MOG-ON eyes compared with healthy controls (all P < 0.05). There were no significant differences in the MD, RNFL thickness, GCIPL thickness, or vessel densities between the AQP4-ON and MOG-ON eyes (all P > 0.05). However, the BCVA was significantly worse in AQP4-ON eyes than in MOG-ON eyes (P = 0.001). The peripapillary vessel density was significantly correlated with the BCVA and MD in AQP4-ON eyes and with MD in MOG-ON eyes (all P < 0.05). CONCLUSIONS: MOG-ON and AQP4-ON are associated with severe visual dysfunction, as well as retinal structural and vascular damage. The extent of visual dysfunction was strongly correlated with the peripapillary vessel density. Although we found no significant difference in the MD between MOG-ON and AQP4-ON, which are characterized by comparable vascular and structural damage within the peripapillary and parafoveal areas, the BCVA was worse in AQP4-ON eyes than in MOG-ON eyes.
OBJECTIVE: To compare the retinal vascular network and structure of optic neuritis associated with myelin oligodendrocyte glycoprotein antibodies (MOG-ON) or aquaporin-4 antibodies (AQP4-ON). METHODS: Nineteen patients with MOG-ON (29 eyes), 24 patients with AQP4-ON (43 eyes), and 25 healthy participants (50 eyes) were enrolled. The best-corrected visual acuity (BCVA), mean deviation (MD), retinal nerve fiber layer (RNFL) thickness, parafoveal ganglion cell and inner plexiform layer (GCIPL) thickness, and vessel densities in the peripapillary and parafoveal areas were measured. RESULTS: The BCVA, RNFL thickness, GCIPL thickness, and vessel densities in the peripapillary and parafoveal areas were significantly decreased in the AQP4-ON and MOG-ON eyes compared with healthy controls (all P < 0.05). There were no significant differences in the MD, RNFL thickness, GCIPL thickness, or vessel densities between the AQP4-ON and MOG-ON eyes (all P > 0.05). However, the BCVA was significantly worse in AQP4-ON eyes than in MOG-ON eyes (P = 0.001). The peripapillary vessel density was significantly correlated with the BCVA and MD in AQP4-ON eyes and with MD in MOG-ON eyes (all P < 0.05). CONCLUSIONS: MOG-ON and AQP4-ON are associated with severe visual dysfunction, as well as retinal structural and vascular damage. The extent of visual dysfunction was strongly correlated with the peripapillary vessel density. Although we found no significant difference in the MD between MOG-ON and AQP4-ON, which are characterized by comparable vascular and structural damage within the peripapillary and parafoveal areas, the BCVA was worse in AQP4-ON eyes than in MOG-ON eyes.
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Authors: Sudarshini Ramanathan; Stephen W Reddel; Andrew Henderson; John D E Parratt; Michael Barnett; Prudence N Gatt; Vera Merheb; Raani-Yogeeta Anusuiya Kumaran; Karrnan Pathmanandavel; Nese Sinmaz; Mahtab Ghadiri; Con Yiannikas; Steve Vucic; Graeme Stewart; Andrew F Bleasel; David Booth; Victor S C Fung; Russell C Dale; Fabienne Brilot Journal: Neurol Neuroimmunol Neuroinflamm Date: 2014-10-29