Juntao Huang1,2, Bing Mei Teh3,4,5, Chongchang Zhou1,2, Yunbin Shi1,2, Yi Shen6,7. 1. Department of Otolaryngology Head and Neck Surgery, Ningbo Medical Center (Ningbo Lihuili Hospital), The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China. 2. School of Medicine, Ningbo University, Ningbo, Zhejiang, China. 3. Department of Ear Nose and Throat, Head and Neck Surgery, Eastern Health, Box Hill, VIC, Australia. 4. Department of Otolaryngology, Head and Neck Surgery, Monash Health, Clayton, VIC, Australia. 5. Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia. 6. Department of Otolaryngology Head and Neck Surgery, Ningbo Medical Center (Ningbo Lihuili Hospital), The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China. tyzdhs@163.com. 7. School of Medicine, Ningbo University, Ningbo, Zhejiang, China. tyzdhs@163.com.
Abstract
PURPOSE: Platelet-rich fibrin (PRF) results in satisfactory wound healing. This analysis focuses on assessing the effectiveness of PRF in the treatment of tympanic membrane (TM) perforations. MATERIALS AND METHODS: The literature was searched using PubMed, Embase, Cochrane Library and Web of Science databases from inception to February 28th, 2021. The following healing and hearing outcomes were measured: closure rate, pre-and postoperative auditory results, and incidence of postoperative infections. Data were pooled and expressed as the odds ratio (OR). RESULTS: Ten studies were eligible for qualitative review, and seven of them were included for the final quantitative comparison. The OR for the closure rate of acute perforations was 4.30 (95% CI 1.35-13.70, I2 = 0%), and the OR in the chronic subgroup was 5.42 (95% CI 2.57-11.43, I2 = 0%). The total OR value for the completed closure rate was 5.10 (95% CI 2.72-9.54, I2 = 0%), indicating that the utilization of PRF can enhance the closure of both acute and chronic perforations. The qualitative review did not find improved hearing results with the use of PRF. In addition to promoting closure, PRF can reduce the incidence of infections (OR = 0.14). The sensitivity analysis did not change the final results, and there was no publication bias in this analysis. CONCLUSION: PRF can increase the closure rate of acute perforations, enhance the survival rate of autografts in TM surgeries and reduce the incidence of infections. However, the literature indicates that PRF does not influence the hearing outcomes. This study shows that PRF is an effective agent for TM regeneration.
PURPOSE: Platelet-rich fibrin (PRF) results in satisfactory wound healing. This analysis focuses on assessing the effectiveness of PRF in the treatment of tympanic membrane (TM) perforations. MATERIALS AND METHODS: The literature was searched using PubMed, Embase, Cochrane Library and Web of Science databases from inception to February 28th, 2021. The following healing and hearing outcomes were measured: closure rate, pre-and postoperative auditory results, and incidence of postoperative infections. Data were pooled and expressed as the odds ratio (OR). RESULTS: Ten studies were eligible for qualitative review, and seven of them were included for the final quantitative comparison. The OR for the closure rate of acute perforations was 4.30 (95% CI 1.35-13.70, I2 = 0%), and the OR in the chronic subgroup was 5.42 (95% CI 2.57-11.43, I2 = 0%). The total OR value for the completed closure rate was 5.10 (95% CI 2.72-9.54, I2 = 0%), indicating that the utilization of PRF can enhance the closure of both acute and chronic perforations. The qualitative review did not find improved hearing results with the use of PRF. In addition to promoting closure, PRF can reduce the incidence of infections (OR = 0.14). The sensitivity analysis did not change the final results, and there was no publication bias in this analysis. CONCLUSION: PRF can increase the closure rate of acute perforations, enhance the survival rate of autografts in TM surgeries and reduce the incidence of infections. However, the literature indicates that PRF does not influence the hearing outcomes. This study shows that PRF is an effective agent for TM regeneration.
Authors: Mehmet Habesoglu; Cagatay Oysu; Serap Sahin; Asli Sahin-Yilmaz; Deniz Korkmaz; Ahmet Tosun; Ahmet Karaaslan Journal: J Craniofac Surg Date: 2014-11 Impact factor: 1.046
Authors: Yi Shen; Sharon Leanne Redmond; Bing Mei Teh; Sheng Yan; Yan Wang; Lin Zhou; Charley A Budgeon; Robert Henry Eikelboom; Marcus David Atlas; Rodney James Dilley; Minghao Zheng; Robert Jeffery Marano Journal: Tissue Eng Part A Date: 2012-12-10 Impact factor: 3.845
Authors: Yi Shen; Sharon L Redmond; Bing Mei Teh; Sheng Yan; Yan Wang; Marcus D Atlas; Rodney J Dilley; Minghao Zheng; Robert J Marano Journal: Laryngoscope Date: 2013-03-27 Impact factor: 3.325