Wanting Shao1,2, Christina Kuhn3, Doris Mayr4, Nina Ditsch3, Magdalena Kailuwait1, Verena Wolf1, Nadia Harbeck1, Sven Mahner1, Udo Jeschke5,6, Vincent Cavaillès7, Sophie Sixou1,8,9. 1. Department of Obstetrics and Gynecology, Breast Center, LMU University Hospital, Munich, Germany. 2. Department of Breast Center, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China. 3. Department of Gynecology and Obstetrics, University Hospital Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany. 4. Department of Pathology, LMU Munich, Munich, Germany. 5. Department of Obstetrics and Gynecology, Breast Center, LMU University Hospital, Munich, Germany. udo.jeschke@med.uni-muenchen.de. 6. Department of Gynecology and Obstetrics, University Hospital Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany. udo.jeschke@med.uni-muenchen.de. 7. IRCM-Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Parc Euromédecine, 208 rue des Apothicaires, F-34298, Montpellier, France. 8. Faculté Des Sciences Pharmaceutiques, Université Toulouse III - Paul Sabatier, 31062, Toulouse, France. 9. Cholesterol Metabolism and Therapeutic Innovations, Cancer Research Center of Toulouse (CRCT), UMR 1037, INSERM, UPS, Université de Toulouse, CNRS, 31037, Toulouse, France.
Abstract
PURPOSE: The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patient survival. METHODS: In a well-characterized cohort of 305 primary BC, subcellular distribution of LXR was evaluated by immunohistochemistry. Correlations with clinicopathological characteristics as well as with patient outcome were analyzed. RESULTS: LXR was frequently localized in both nuclei and cytoplasms of BC cells, with stronger staining in nuclei. Total and nuclear LXR expression was positively correlated with ER and PR status. Overall survival analysis demonstrated that cytoplasmic LXR was significantly correlated with poor survival and appeared as an independent marker of poor prognosis, in stage I but not in stage II-III tumors CONCLUSION: Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.
PURPOSE: The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patient survival. METHODS: In a well-characterized cohort of 305 primary BC, subcellular distribution of LXR was evaluated by immunohistochemistry. Correlations with clinicopathological characteristics as well as with patient outcome were analyzed. RESULTS:LXR was frequently localized in both nuclei and cytoplasms of BC cells, with stronger staining in nuclei. Total and nuclear LXR expression was positively correlated with ER and PR status. Overall survival analysis demonstrated that cytoplasmic LXR was significantly correlated with poor survival and appeared as an independent marker of poor prognosis, in stage I but not in stage II-III tumors CONCLUSION: Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.
Authors: S Jalaguier; C Teyssier; T Nait Achour; A Lucas; S Bonnet; C Rodriguez; N Elarouci; M Lapierre; V Cavaillès Journal: Oncogene Date: 2017-04-17 Impact factor: 9.867
Authors: Charlotte Le Cornet; Britta Walter; Disorn Sookthai; Theron S Johnson; Tilman Kühn; Ester Herpel; Rudolf Kaaks; Renée T Fortner Journal: Breast Cancer Res Date: 2020-02-19 Impact factor: 6.466