Injectable self-healing bioactive antioxidative one-component poly(salicylic acid) hydrogel with strong ultraviolet-shielding for preventing skin light injury.

The design and development of one-component temperature-sensitive bioactive hydrogel with multifunctional properties for protecting skin against light injury remain a challenge. Herein, we report a bioactive multifunctional poly(salicylic acid)-F127-poly(salicylic acid) copolymer hydrogel (FPSa) with one-component for potential skin protection applications. The FPSa hydrogel possesses the thermosensitivity (23 °C), injectability, self-healing ability, ultraviolet shielding (shielding the wavelength between 280 and 370 nm), and antioxidation activity (above 70%), and also showed the good cytocompatibility (cell survival rate >90% and hemolysis rate less than 5%) and biodegradability (90% weight loss at 3 days). The in vivo animal model showed that FPSa hydrogel could effectively protect the skin tissue and prevent the ultraviolet induced injury. This study can provide a strategy to design multifunctional bioactive hydrogel with simple composition for disease therapy and regenerative medicine.