Hsien-Yin Liao1, Yi-Wen Lin2,3. 1. College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, 40402, Taiwan. 2. College of Chinese Medicine, Graduate Institute of Acupuncture Science, China Medical University, 91 Hsueh-Shih Road, Taichung, 40402, Taiwan. yiwenlin@mail.cmu.edu.tw. 3. Chinese Medicine Research Center, China Medical University, Taichung, 40402, Taiwan. yiwenlin@mail.cmu.edu.tw.
Abstract
BACKGROUND: The treatment, and efficacy thereof, is considered to be inadequate with specificity to alleviation of Fibromyalgia and its associated pain. Fibromyalgia patients suffer from chronic and persistent widespread pain and generalized tenderness. Transient receptor potential V1 (TRPV1), which is reported as a Ca2+ permeable ion channel that can be activated by inflammation, is reported to be involved in the development of fibromyalgia pain. METHODS: The current study explored the TRPV1 channel functions as a noxious sensory input in mice cold stress model. It remains unknown whether electroacupuncture (EA) attenuates fibromyalgia pain or affects the TRPV1 pathway. RESULTS: We show that cold stress increases mechanical and thermal pain (day 7: mechanical: 1.69 ± 0.41 g; thermal: 4.68 ± 0.56 s), and that EA and Trpv1 deletion counter this increase. EA and Trpv1 deletion reduced the cold stress-induced increase in inflammatory mediators and TRPV1-related molecules in the hypothalamus, periaqueductal gray (PAG), and cerebellum of mice. CONCLUSIONS: Our results imply that EA has an analgesic effect associated with TRPV1 downregulation. We provide novel evidence that these inflammatory mediators can modulate the TRPV1 signaling pathway and suggest new potential therapeutic targets for fibromyalgia pain.
BACKGROUND: The treatment, and efficacy thereof, is considered to be inadequate with specificity to alleviation of Fibromyalgia and its associated pain. Fibromyalgiapatients suffer from chronic and persistent widespread pain and generalized tenderness. Transient receptor potential V1 (TRPV1), which is reported as a Ca2+ permeable ion channel that can be activated by inflammation, is reported to be involved in the development of fibromyalgia pain. METHODS: The current study explored the TRPV1 channel functions as a noxious sensory input in micecold stress model. It remains unknown whether electroacupuncture (EA) attenuates fibromyalgia pain or affects the TRPV1 pathway. RESULTS: We show that cold stress increases mechanical and thermal pain (day 7: mechanical: 1.69 ± 0.41 g; thermal: 4.68 ± 0.56 s), and that EA and Trpv1 deletion counter this increase. EA and Trpv1 deletion reduced the cold stress-induced increase in inflammatory mediators and TRPV1-related molecules in the hypothalamus, periaqueductal gray (PAG), and cerebellum of mice. CONCLUSIONS: Our results imply that EA has an analgesic effect associated with TRPV1 downregulation. We provide novel evidence that these inflammatory mediators can modulate the TRPV1 signaling pathway and suggest new potential therapeutic targets for fibromyalgia pain.
Authors: Nilesh M Agalave; Max Larsson; Sally Abdelmoaty; Jie Su; Azar Baharpoor; Peter Lundbäck; Karin Palmblad; Ulf Andersson; Helena Harris; Camilla I Svensson Journal: Pain Date: 2014-06-20 Impact factor: 6.961
Authors: Sergio I Valdés-Ferrer; Julien Papoin; Meghan E Dancho; Peder S Olofsson; Jianhua Li; Jeffrey M Lipton; Patricia Avancena; Huan Yang; Yong-Rui Zou; Sangeeta S Chavan; Bruce T Volpe; Sara Gardenghi; Stefano Rivella; Betty Diamond; Ulf Andersson; Bettie M Steinberg; Lionel Blanc; Kevin J Tracey Journal: Mol Med Date: 2015-12-29 Impact factor: 6.354