Literature DB >> 34079852

Diversity on demand: multi-ancestry meta-analysis improves genetic risk prediction in prostate cancer.

Andres F Leon1, Cindy H Chau1, Douglas K Price1, William D Figg1.   

Abstract

Several genome-wide association studies have been conducted to identify genetic risk factors associated with prostate cancer, but their ability to discover new genetic variants and their applicability across ancestry groups have been limited by their lack of genetic diversity, owing to an underrepresentation of non-European populations. A recent meta-analysis published in Nature Genetics by Conti et al. has used a multi-ancestry approach to identify 86 new genetic loci associated with prostate cancer risk, refine leads in known risk regions, and develop a genetic risk score that is transferable across population groups. The findings of this study represent a significant advancement in genetic risk prediction for prostate cancer and their incorporation into standard screening protocols may lead to significant improvements in clinical outcomes. AJCEU
Copyright © 2021.

Entities:  

Keywords:  Prostate cancer; genome-wide association study; health disparities; multi-ancestry

Year:  2021        PMID： 34079852      PMCID： PMC8165707     

Source DB:  PubMed          Journal:  Am J Clin Exp Urol        ISSN： 2330-1910


  8 in total

1.  Leveraging genetic variability across populations for the identification of causal variants.

Authors:  Noah Zaitlen; Bogdan Paşaniuc; Tom Gur; Elad Ziv; Eran Halperin
Journal:  Am J Hum Genet       Date:  2010-01       Impact factor: 11.025

2.  The GWAS Diversity Monitor tracks diversity by disease in real time.

Authors:  Melinda C Mills; Charles Rahal
Journal:  Nat Genet       Date:  2020-03       Impact factor: 38.330

3.  Cancer Statistics, 2021.

Authors:  Rebecca L Siegel; Kimberly D Miller; Hannah E Fuchs; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2021-01-12       Impact factor: 508.702

4.  The Missing Diversity in Human Genetic Studies.

Authors:  Giorgio Sirugo; Scott M Williams; Sarah A Tishkoff
Journal:  Cell       Date:  2019-03-21       Impact factor: 41.582

5.  An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.

Authors:  Michał Kiciński; Jaco Vangronsveld; Tim S Nawrot
Journal:  PLoS One       Date:  2011-10-31       Impact factor: 3.240

Review 6.  Improving reporting standards for polygenic scores in risk prediction studies.

Authors:  Hannah Wand; Samuel A Lambert; Cecelia Tamburro; Michael A Iacocca; Jack W O'Sullivan; Catherine Sillari; Iftikhar J Kullo; Robb Rowley; Jacqueline S Dron; Deanna Brockman; Eric Venner; Mark I McCarthy; Antonis C Antoniou; Douglas F Easton; Robert A Hegele; Amit V Khera; Nilanjan Chatterjee; Charles Kooperberg; Karen Edwards; Katherine Vlessis; Kim Kinnear; John N Danesh; Helen Parkinson; Erin M Ramos; Megan C Roberts; Kelly E Ormond; Muin J Khoury; A Cecile J W Janssens; Katrina A B Goddard; Peter Kraft; Jaqueline A L MacArthur; Michael Inouye; Genevieve L Wojcik
Journal:  Nature       Date:  2021-03-10       Impact factor: 69.504

7.  A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Authors:  Ali Amin Al Olama; Zsofia Kote-Jarai; Sonja I Berndt; David V Conti; Fredrick Schumacher; Ying Han; Sara Benlloch; Dennis J Hazelett; Zhaoming Wang; Ed Saunders; Daniel Leongamornlert; Sara Lindstrom; Sara Jugurnauth-Little; Tokhir Dadaev; Malgorzata Tymrakiewicz; Daniel O Stram; Kristin Rand; Peggy Wan; Alex Stram; Xin Sheng; Loreall C Pooler; Karen Park; Lucy Xia; Jonathan Tyrer; Laurence N Kolonel; Loic Le Marchand; Robert N Hoover; Mitchell J Machiela; Merideth Yeager; Laurie Burdette; Charles C Chung; Amy Hutchinson; Kai Yu; Chee Goh; Mahbubl Ahmed; Koveela Govindasami; Michelle Guy; Teuvo L J Tammela; Anssi Auvinen; Tiina Wahlfors; Johanna Schleutker; Tapio Visakorpi; Katri A Leinonen; Jianfeng Xu; Markus Aly; Jenny Donovan; Ruth C Travis; Tim J Key; Afshan Siddiq; Federico Canzian; Kay-Tee Khaw; Atsushi Takahashi; Michiaki Kubo; Paul Pharoah; Nora Pashayan; Maren Weischer; Borge G Nordestgaard; Sune F Nielsen; Peter Klarskov; Martin Andreas Røder; Peter Iversen; Stephen N Thibodeau; Shannon K McDonnell; Daniel J Schaid; Janet L Stanford; Suzanne Kolb; Sarah Holt; Beatrice Knudsen; Antonio Hurtado Coll; Susan M Gapstur; W Ryan Diver; Victoria L Stevens; Christiane Maier; Manuel Luedeke; Kathleen Herkommer; Antje E Rinckleb; Sara S Strom; Curtis Pettaway; Edward D Yeboah; Yao Tettey; Richard B Biritwum; Andrew A Adjei; Evelyn Tay; Ann Truelove; Shelley Niwa; Anand P Chokkalingam; Lisa Cannon-Albright; Cezary Cybulski; Dominika Wokołorczyk; Wojciech Kluźniak; Jong Park; Thomas Sellers; Hui-Yi Lin; William B Isaacs; Alan W Partin; Hermann Brenner; Aida Karina Dieffenbach; Christa Stegmaier; Constance Chen; Edward L Giovannucci; Jing Ma; Meir Stampfer; Kathryn L Penney; Lorelei Mucci; Esther M John; Sue A Ingles; Rick A Kittles; Adam B Murphy; Hardev Pandha; Agnieszka Michael; Andrzej M Kierzek; William Blot; Lisa B Signorello; Wei Zheng; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Barbara Nemesure; John Carpten; Cristina Leske; Suh-Yuh Wu; Anselm Hennis; Adam S Kibel; Benjamin A Rybicki; Christine Neslund-Dudas; Ann W Hsing; Lisa Chu; Phyllis J Goodman; Eric A Klein; S Lilly Zheng; Jyotsna Batra; Judith Clements; Amanda Spurdle; Manuel R Teixeira; Paula Paulo; Sofia Maia; Chavdar Slavov; Radka Kaneva; Vanio Mitev; John S Witte; Graham Casey; Elizabeth M Gillanders; Daniella Seminara; Elio Riboli; Freddie C Hamdy; Gerhard A Coetzee; Qiyuan Li; Matthew L Freedman; David J Hunter; Kenneth Muir; Henrik Gronberg; David E Neal; Melissa Southey; Graham G Giles; Gianluca Severi; Michael B Cook; Hidewaki Nakagawa; Fredrik Wiklund; Peter Kraft; Stephen J Chanock; Brian E Henderson; Douglas F Easton; Rosalind A Eeles; Christopher A Haiman
Journal:  Nat Genet       Date:  2014-09-14       Impact factor: 38.330

8.  Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Authors:  David V Conti; Burcu F Darst; Lilit C Moss; Edward J Saunders; Xin Sheng; Alisha Chou; Fredrick R Schumacher; Ali Amin Al Olama; Sara Benlloch; Tokhir Dadaev; Mark N Brook; Ali Sahimi; Thomas J Hoffmann; Atushi Takahashi; Koichi Matsuda; Yukihide Momozawa; Masashi Fujita; Kenneth Muir; Artitaya Lophatananon; Peggy Wan; Loic Le Marchand; Lynne R Wilkens; Victoria L Stevens; Susan M Gapstur; Brian D Carter; Johanna Schleutker; Teuvo L J Tammela; Csilla Sipeky; Anssi Auvinen; Graham G Giles; Melissa C Southey; Robert J MacInnis; Cezary Cybulski; Dominika Wokołorczyk; Jan Lubiński; David E Neal; Jenny L Donovan; Freddie C Hamdy; Richard M Martin; Børge G Nordestgaard; Sune F Nielsen; Maren Weischer; Stig E Bojesen; Martin Andreas Røder; Peter Iversen; Jyotsna Batra; Suzanne Chambers; Leire Moya; Lisa Horvath; Judith A Clements; Wayne Tilley; Gail P Risbridger; Henrik Gronberg; Markus Aly; Robert Szulkin; Martin Eklund; Tobias Nordström; Nora Pashayan; Alison M Dunning; Maya Ghoussaini; Ruth C Travis; Tim J Key; Elio Riboli; Jong Y Park; Thomas A Sellers; Hui-Yi Lin; Demetrius Albanes; Stephanie J Weinstein; Lorelei A Mucci; Edward Giovannucci; Sara Lindstrom; Peter Kraft; David J Hunter; Kathryn L Penney; Constance Turman; Catherine M Tangen; Phyllis J Goodman; Ian M Thompson; Robert J Hamilton; Neil E Fleshner; Antonio Finelli; Marie-Élise Parent; Janet L Stanford; Elaine A Ostrander; Milan S Geybels; Stella Koutros; Laura E Beane Freeman; Meir Stampfer; Alicja Wolk; Niclas Håkansson; Gerald L Andriole; Robert N Hoover; Mitchell J Machiela; Karina Dalsgaard Sørensen; Michael Borre; William J Blot; Wei Zheng; Edward D Yeboah; James E Mensah; Yong-Jie Lu; Hong-Wei Zhang; Ninghan Feng; Xueying Mao; Yudong Wu; Shan-Chao Zhao; Zan Sun; Stephen N Thibodeau; Shannon K McDonnell; Daniel J Schaid; Catharine M L West; Neil Burnet; Gill Barnett; Christiane Maier; Thomas Schnoeller; Manuel Luedeke; Adam S Kibel; Bettina F Drake; Olivier Cussenot; Géraldine Cancel-Tassin; Florence Menegaux; Thérèse Truong; Yves Akoli Koudou; Esther M John; Eli Marie Grindedal; Lovise Maehle; Kay-Tee Khaw; Sue A Ingles; Mariana C Stern; Ana Vega; Antonio Gómez-Caamaño; Laura Fachal; Barry S Rosenstein; Sarah L Kerns; Harry Ostrer; Manuel R Teixeira; Paula Paulo; Andreia Brandão; Stephen Watya; Alexander Lubwama; Jeannette T Bensen; Elizabeth T H Fontham; James Mohler; Jack A Taylor; Manolis Kogevinas; Javier Llorca; Gemma Castaño-Vinyals; Lisa Cannon-Albright; Craig C Teerlink; Chad D Huff; Sara S Strom; Luc Multigner; Pascal Blanchet; Laurent Brureau; Radka Kaneva; Chavdar Slavov; Vanio Mitev; Robin J Leach; Brandi Weaver; Hermann Brenner; Katarina Cuk; Bernd Holleczek; Kai-Uwe Saum; Eric A Klein; Ann W Hsing; Rick A Kittles; Adam B Murphy; Christopher J Logothetis; Jeri Kim; Susan L Neuhausen; Linda Steele; Yuan Chun Ding; William B Isaacs; Barbara Nemesure; Anselm J M Hennis; John Carpten; Hardev Pandha; Agnieszka Michael; Kim De Ruyck; Gert De Meerleer; Piet Ost; Jianfeng Xu; Azad Razack; Jasmine Lim; Soo-Hwang Teo; Lisa F Newcomb; Daniel W Lin; Jay H Fowke; Christine Neslund-Dudas; Benjamin A Rybicki; Marija Gamulin; Davor Lessel; Tomislav Kulis; Nawaid Usmani; Sandeep Singhal; Matthew Parliament; Frank Claessens; Steven Joniau; Thomas Van den Broeck; Manuela Gago-Dominguez; Jose Esteban Castelao; Maria Elena Martinez; Samantha Larkin; Paul A Townsend; Claire Aukim-Hastie; William S Bush; Melinda C Aldrich; Dana C Crawford; Shiv Srivastava; Jennifer C Cullen; Gyorgy Petrovics; Graham Casey; Monique J Roobol; Guido Jenster; Ron H N van Schaik; Jennifer J Hu; Maureen Sanderson; Rohit Varma; Roberta McKean-Cowdin; Mina Torres; Nicholas Mancuso; Sonja I Berndt; Stephen K Van Den Eeden; Douglas F Easton; Stephen J Chanock; Michael B Cook; Fredrik Wiklund; Hidewaki Nakagawa; John S Witte; Rosalind A Eeles; Zsofia Kote-Jarai; Christopher A Haiman
Journal:  Nat Genet       Date:  2021-01-04       Impact factor: 38.330
  8 in total

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