Yao-Kuang Huang1,2, Chin-Kuo Lin2,3, Che-Chuan Wang4, Jinn-Rung Kuo4, Chien-Fu Lai5, Chien-Wei Chen1,2, Bor-Shyh Lin5. 1. Division of Cardiovascular Surgery and Radiology, Chiayi Chang Gung Memorial Hospital, Putz, Chiayi. 2. College of Medicine, Chang Gung University, Taoyuan. 3. Division of Pulmonary Infection and Critical Care, Department of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Putz, Chiayi. 4. Division of Neurosurgery, Department of Surgery, Chi Mei Medical Center, Tainan. 5. Institute of Imaging and Biomedical Photonics, National Yang Ming Chiao Tung University, Tainan.
Abstract
BACKGROUND: Cerebral perfusion pressure (CPP) calculated by mean arterial pressure (MAP) minus intracranial pressure (ICP) is related to blood flow into the brain and reflects cerebral ischemia and oxygenation indirectly. Near-infrared spectroscopy (NIRS) can assess cerebral ischemia and hypoxia non-invasively and has been widely used in neuroscience. However, the correlation between CPP and NIRS, and its potential application in traumatic brain injury, has seldom been investigated. METHODS: We used a novel wireless NIRS system and commercial ICP and MAP devices to assess the trauma to rat brains using different impact intensity. The relationship between CPP and NIRS parameters with increasing impact strength were investigated. RESULTS: The results showed that changes in CPP (∆CPP), oxy-hemoglobin {∆[HbO2]}, total-hemoglobin {∆[HbT]}, and deoxy-hemoglobin were inversely proportional to the increase in impact intensity, and the correlations between ∆CPP, NIRS parameters {∆[HbO2], and ∆[HbT]} were significant. CONCLUSIONS: The NIRS system can assess cerebral ischemia and oxygenation non-invasively and changes of HbO2 and HbT may be used as reference parameters to assess the level of CPP in an animal model of traumatic brain injury. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: Cerebral perfusion pressure (CPP) calculated by mean arterial pressure (MAP) minus intracranial pressure (ICP) is related to blood flow into the brain and reflects cerebral ischemia and oxygenation indirectly. Near-infrared spectroscopy (NIRS) can assess cerebral ischemia and hypoxia non-invasively and has been widely used in neuroscience. However, the correlation between CPP and NIRS, and its potential application in traumatic brain injury, has seldom been investigated. METHODS: We used a novel wireless NIRS system and commercial ICP and MAP devices to assess the trauma to rat brains using different impact intensity. The relationship between CPP and NIRS parameters with increasing impact strength were investigated. RESULTS: The results showed that changes in CPP (∆CPP), oxy-hemoglobin {∆[HbO2]}, total-hemoglobin {∆[HbT]}, and deoxy-hemoglobin were inversely proportional to the increase in impact intensity, and the correlations between ∆CPP, NIRS parameters {∆[HbO2], and ∆[HbT]} were significant. CONCLUSIONS: The NIRS system can assess cerebral ischemia and oxygenation non-invasively and changes of HbO2 and HbT may be used as reference parameters to assess the level of CPP in an animal model of traumatic brain injury. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Authors: Stuart H Friess; Jill Ralston; Stephanie A Eucker; Mark A Helfaer; Colin Smith; Susan S Margulies Journal: Neurosurgery Date: 2011-11 Impact factor: 4.654
Authors: Mario Forcione; Antonio M Chiarelli; David J Davies; David Perpetuini; Piotr Sawosz; Arcangelo Merla; Antonio Belli Journal: J Cereb Blood Flow Metab Date: 2020-04-28 Impact factor: 6.200
Authors: Julien Adjedj; Fabien Picard; Maarten Vanhaverbeke; Bernard De Bruyne; Alain Cariou; Ming Wu; Stefan Janssens; Olivier Varenne Journal: Intensive Care Med Exp Date: 2018-10-12