Hon Yan Ng1,2, Orlee R Guttman3, Lori B Tucker4. 1. Division of Rheumatology, Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada. hon602@usask.ca. 2. , Edmonton, Canada. hon602@usask.ca. 3. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of British Columbia, Vancouver, Canada. 4. Division of Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Abstract
BACKGROUND: Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been associated with inflammatory bowel disease (IBD). Primary sclerosing cholangitis (PSC) and Autoimmune Hepatitis (AIH) are also uncommon pediatric conditions with a known association with IBD. CASE PRESENTATION: We present a unique case of a pediatric patient with an initial diagnosis of CRMO, with subsequent diagnosis of autoimmune hepatitis and PSC overlap, and eventually IBD. CONCLUSIONS: Patients with CRMO may also develop PSC in addition to IBD, further highlighting the importance of IBD pathophysiology in both conditions. Clinical screening of associated gastrointestinal findings may be of value in patients with CRMO.
BACKGROUND: Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been associated with inflammatory bowel disease (IBD). Primary sclerosing cholangitis (PSC) and Autoimmune Hepatitis (AIH) are also uncommon pediatric conditions with a known association with IBD. CASE PRESENTATION: We present a unique case of a pediatric patient with an initial diagnosis of CRMO, with subsequent diagnosis of autoimmune hepatitis and PSC overlap, and eventually IBD. CONCLUSIONS:Patients with CRMO may also develop PSC in addition to IBD, further highlighting the importance of IBD pathophysiology in both conditions. Clinical screening of associated gastrointestinal findings may be of value in patients with CRMO.
Authors: Henner Morbach; Anke Dick; Christine Beck; Martin Stenzel; Hans Konrad Müller-Hermelink; Peter Raab; Hemann Josef Girschick Journal: Rheumatol Int Date: 2009-07-05 Impact factor: 2.631