Ahmed T Alahmar1, Pallav Sengupta2, Sulagna Dutta2, Aldo E Calogero3. 1. Department of Medical Physiology, College of Medicine, University of Babylon, Hillah, Iraq. 2. Department of Physiology, MAHSA University, Selangor, Malaysia. 3. Division of Andrology and Endocrinology, University Teaching Hospital "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy.
Abstract
OBJECTIVE: Oxidative stress (OS) plays a key role in the etiology of unexplained male infertility. Coenzyme Q10 (CoQ10) is a potent antioxidant that may improve semen quality and OS in infertile men with idiopathic oligoasthenoteratospermia (OAT), but the underlying mechanism is unknown. Therefore, the present study was undertaken to investigate the effect of CoQ10 on OS markers and sperm DNA damage in infertile patients with idiopathic OAT. METHODS: This prospective controlled study included 50 patients with idiopathic OAT and 50 fertile men who served as controls. All patients underwent a comprehensive medical assessment. Patients and controls received 200 mg of oral CoQ10 once daily for 3 months. Semen and blood were collected and analyzed for sperm parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity, catalase, sperm DNA fragmentation (SDF), and serum hormonal profile. RESULTS: The administration of CoQ10 to patients with idiopathic OAT significantly improved sperm quality and seminal antioxidant status and significantly reduced total ROS and SDF levels compared to pretreatment values. CONCLUSION: CoQ10, at a dose of 200 mg/day for 3 months, may be a potential therapy for infertile patients with idiopathic OAT, as it improved sperm parameters and reduced OS and SDF in these patients.
OBJECTIVE: Oxidative stress (OS) plays a key role in the etiology of unexplained male infertility. Coenzyme Q10 (CoQ10) is a potent antioxidant that may improve semen quality and OS in infertilemen with idiopathic oligoasthenoteratospermia (OAT), but the underlying mechanism is unknown. Therefore, the present study was undertaken to investigate the effect of CoQ10 on OS markers and sperm DNA damage in infertilepatients with idiopathic OAT. METHODS: This prospective controlled study included 50 patients with idiopathic OAT and 50 fertile men who served as controls. All patients underwent a comprehensive medical assessment. Patients and controls received 200 mg of oral CoQ10 once daily for 3 months. Semen and blood were collected and analyzed for sperm parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity, catalase, sperm DNA fragmentation (SDF), and serum hormonal profile. RESULTS: The administration of CoQ10 to patients with idiopathic OAT significantly improved sperm quality and seminal antioxidant status and significantly reduced total ROS and SDF levels compared to pretreatment values. CONCLUSION:CoQ10, at a dose of 200 mg/day for 3 months, may be a potential therapy for infertilepatients with idiopathic OAT, as it improved sperm parameters and reduced OS and SDF in these patients.
Entities:
Keywords:
Coenzyme Q10; Male infertility; Oxidative stress; Sperm DNA fragmentation
Authors: Hossam R El-Sherbiny; Elshymaa A Abdelnaby; K H El-Shahat; Noha Y Salem; Eman S Ramadan; Shimaa G Yehia; Mohamed Fathi Journal: Vet Res Commun Date: 2022-09-01 Impact factor: 2.816