Thomas P Lodise1, Teena Chopra2, Brian H Nathanson3, Katherine Sulham4. 1. Albany College of Pharmacy and Health Sciences, Albany, NY. Electronic address: Thomas.lodise@acphs.edu. 2. Wayne State University, Detroit, MI. 3. OptiStatim LLC, Longmeadow, MA. 4. Spero Therapeutics, Cambridge, MA.
Abstract
BACKGROUND: Hospital admissions for complicated urinary tract infections (cUTI) in the United States are increasing but there are limited information on the acuity of patients who are admitted. OBJECTIVE: Describe hospitalization patterns among adult cUTI patients who present to the hospital with cUTI and to determine the proportion of admissions that were of low acuity. METHODS: A retrospective multi-center analysis using data from the Premier Healthcare Database (2013-2018) was performed. INCLUSION CRITERIA: age ≥ 18 years, cUTI diagnosis, positive blood or urine culture. Hospital admissions were stratified by presence of sepsis, systemic symptoms but no sepsis, and Charlson Comorbidity Index (CCI). RESULTS: 187,789 patients met the inclusion criteria. The mean (SD) age was 59.7 (21.9), 40.4% were male, 29.4% had sepsis, 16.7% had at least 1 systemic symptom (but no sepsis), and 53.9% had no sepsis or systemic symptoms. The median [inter-quartile range] CCI was 1 [0, 3]. Sixty-four percent of patients were admitted to hospital, and 18.9% of admissions occurred in patients with low acuity (no sepsis or systemic symptoms and a CCI ≤ 2). The median [IQR] LOS and costs for low acuity inpatients who were admitted were 3 [2, 5] days and $5,575 [$3,607, $9,133], respectively. CONCLUSION: Nearly 1 in 5 cUTI hospital admissions occurred in patients with low acuity, and therefore may be avoidable.
BACKGROUND: Hospital admissions for complicated urinary tract infections (cUTI) in the United States are increasing but there are limited information on the acuity of patients who are admitted. OBJECTIVE: Describe hospitalization patterns among adult cUTI patients who present to the hospital with cUTI and to determine the proportion of admissions that were of low acuity. METHODS: A retrospective multi-center analysis using data from the Premier Healthcare Database (2013-2018) was performed. INCLUSION CRITERIA: age ≥ 18 years, cUTI diagnosis, positive blood or urine culture. Hospital admissions were stratified by presence of sepsis, systemic symptoms but no sepsis, and Charlson Comorbidity Index (CCI). RESULTS: 187,789 patients met the inclusion criteria. The mean (SD) age was 59.7 (21.9), 40.4% were male, 29.4% had sepsis, 16.7% had at least 1 systemic symptom (but no sepsis), and 53.9% had no sepsis or systemic symptoms. The median [inter-quartile range] CCI was 1 [0, 3]. Sixty-four percent of patients were admitted to hospital, and 18.9% of admissions occurred in patients with low acuity (no sepsis or systemic symptoms and a CCI ≤ 2). The median [IQR] LOS and costs for low acuity inpatients who were admitted were 3 [2, 5] days and $5,575 [$3,607, $9,133], respectively. CONCLUSION: Nearly 1 in 5 cUTI hospital admissions occurred in patients with low acuity, and therefore may be avoidable.
Authors: Thomas P Lodise; Janna Manjelievskaia; Elizabeth Hoit Marchlewicz; Mauricio Rodriguez Journal: Open Forum Infect Dis Date: 2022-06-20 Impact factor: 4.423
Authors: Thomas P Lodise; Teena Chopra; Brian H Nathanson; Katherine Sulham; Mauricio Rodriguez Journal: Open Forum Infect Dis Date: 2022-06-24 Impact factor: 4.423