Literature DB >> 34075728

Advanced Human BBB-on-a-Chip: A New Platform for Alzheimer's Disease Studies.

Jeong-Kee Yoon1, Jaehoon Kim2, Zachary Shah3, Ashi Awasthi3, Advay Mahajan3, YongTae Kim1,2,3,4,5.   

Abstract

The blood-brain barrier (BBB) is a unique vascular structure that serves as a molecular transport gateway for the maintenance of brain homeostasis. Chronic disruption or breakdown of the BBB reportedly leads to neurodegenerative diseases. Nonetheless, research on human BBB pathophysiology and drug development remains highly dependent on studies using inherently different animals. Moreover, more studies have shown that animal models are not appropriate in modeling Alzheimer's disease (AD), underlining the importance of in vitro models of the human BBB with physiological relevance. In this review, recent advances in human BBB-on-a-chip technologies are highlighted and their potential for pathogenesis studies and drug prescreening for AD treatment are discussed.
© 2021 Wiley-VCH GmbH.

Entities:  

Keywords:  Alzheimer's disease; blood−brain barrier; drug delivery; neurodegeneration; organs-on-a-chip

Mesh：

Year:  2021        PMID： 34075728      PMCID： PMC8349886          DOI： 10.1002/adhm.202002285

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   11.092


  101 in total

1.  Microchip electrophoresis profiling of Aβ peptides in the cerebrospinal fluid of patients with Alzheimer's disease.

Authors:  Mohamad Reza Mohamadi; Zuzana Svobodova; Romain Verpillot; Hermann Esselmann; Jens Wiltfang; Markus Otto; Myriam Taverna; Zuzana Bilkova; Jean-Louis Viovy
Journal:  Anal Chem       Date:  2010-09-15       Impact factor: 6.986

Review 2.  Immune attack: the role of inflammation in Alzheimer disease.

Authors:  Frank L Heppner; Richard M Ransohoff; Burkhard Becher
Journal:  Nat Rev Neurosci       Date:  2015-06       Impact factor: 34.870

Review 3.  Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier.

Authors:  Jason M Lajoie; Eric V Shusta
Journal:  Annu Rev Pharmacol Toxicol       Date:  2014-10-08       Impact factor: 13.820

4.  Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system.

Authors:  Robert D Bell; Abhay P Sagare; Alan E Friedman; Gurrinder S Bedi; David M Holtzman; Rashid Deane; Berislav V Zlokovic
Journal:  J Cereb Blood Flow Metab       Date:  2006-11-01       Impact factor: 6.200

5.  Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice.

Authors:  Carlijn R Hooijmans; Coen Graven; Pieter J Dederen; Heikki Tanila; Thomas van Groen; Amanda J Kiliaan
Journal:  Brain Res       Date:  2007-09-05       Impact factor: 3.252

6.  Robotic fluidic coupling and interrogation of multiple vascularized organ chips.

Authors:  Richard Novak; Debarun Das; Anna Herland; Ben M Maoz; Mahadevabharath R Somayaji; Rachelle Prantil-Baun; Miles Ingram; Susan Marquez; Aaron Delahanty; Sauveur S F Jeanty; Morgan Burt; Elizabeth Calamari; Angeliki Chalkiadaki; Alexander Cho; Youngjae Choe; David Benson Chou; Michael Cronce; Stephanie Dauth; Toni Divic; Jose Fernandez-Alcon; Thomas Ferrante; John Ferrier; Edward A FitzGerald; Rachel Fleming; Sasan Jalili-Firoozinezhad; Thomas Grevesse; Josue A Goss; Tiama Hamkins-Indik; Olivier Henry; Chris Hinojosa; Tessa Huffstater; Kyung-Jin Jang; Ville Kujala; Lian Leng; Robert Mannix; Yuka Milton; Janna Nawroth; Bret A Nestor; Carlos F Ng; Blakely O'Connor; Tae-Eun Park; Henry Sanchez; Josiah Sliz; Alexandra Sontheimer-Phelps; Ben Swenor; Guy Thompson; George J Touloumes; Zachary Tranchemontagne; Norman Wen; Moran Yadid; Anthony Bahinski; Geraldine A Hamilton; Daniel Levner; Oren Levy; Andrzej Przekwas; Kevin K Parker; Donald E Ingber
Journal:  Nat Biomed Eng       Date:  2020-01-27       Impact factor: 25.671

7.  Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.

Authors:  Y Iturria-Medina; R C Sotero; P J Toussaint; J M Mateos-Pérez; A C Evans
Journal:  Nat Commun       Date:  2016-06-21       Impact factor: 14.919

8.  Microengineered human blood-brain barrier platform for understanding nanoparticle transport mechanisms.

Authors:  Song Ih Ahn; Yoshitaka J Sei; Hyun-Ji Park; Jinhwan Kim; Yujung Ryu; Jeongmoon J Choi; Hak-Joon Sung; Tobey J MacDonald; Allan I Levey; YongTae Kim
Journal:  Nat Commun       Date:  2020-01-10       Impact factor: 14.919

9.  A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport.

Authors:  Nienke R Wevers; Dhanesh G Kasi; Taylor Gray; Karlijn J Wilschut; Benjamin Smith; Remko van Vught; Fumitaka Shimizu; Yasuteru Sano; Takashi Kanda; Graham Marsh; Sebastiaan J Trietsch; Paul Vulto; Henriëtte L Lanz; Birgit Obermeier
Journal:  Fluids Barriers CNS       Date:  2018-08-31

10.  CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology.

Authors:  J S Miners; P G Kehoe; S Love; H Zetterberg; K Blennow
Journal:  Alzheimers Res Ther       Date:  2019-09-14       Impact factor: 6.982
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  2 in total

Review 1.  Modeling Neurodegenerative Diseases Using In Vitro Compartmentalized Microfluidic Devices.

Authors:  Louise Miny; Benoît G C Maisonneuve; Isabelle Quadrio; Thibault Honegger
Journal:  Front Bioeng Biotechnol       Date:  2022-06-24

Review 2.  Blood-brain barrier-on-a-chip for brain disease modeling and drug testing.

Authors:  Baofang Cui; Seung-Woo Cho
Journal:  BMB Rep       Date:  2022-05       Impact factor: 5.041
  2 in total

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