Mogens Bernsdorf1, Annika Loft2, Anne Kiil Berthelsen3,2, Julie Kjems3, Ivan Richter Vogelius3, Christian von Buchwald4, Claus Andrup Kristensen3, Anita Birgitte Gothelf3, Jeppe Friborg3. 1. Department of Oncology 5073, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100-DK, Copenhagen, Denmark. mogens.bernsdorf@regionh.dk. 2. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 3. Department of Oncology 5073, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100-DK, Copenhagen, Denmark. 4. Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Abstract
PURPOSE: Whole-body FDG-PET-CT is widely used at diagnosis of squamous cell carcinoma of the head and neck (SCCHN) but may identify suspicious lesions outside the neck that require investigation. This study evaluated the impact of smoking and P16-status on the incidence of malignant disease outside the head and neck region in newly diagnosed patients with SCCHN. METHODS: All PET-positive foci outside the head-neck area were registered in 1069 patients planned for postoperative or curative intent radiotherapy with whole-body FDG-PET/CT from 2006 to 2012. All patient files were retrospectively investigated and clinical parameters, tobacco use, HPV (P16)-status and subsequent malignant disease registered. RESULTS: Malignancy outside the neck was diagnosed in 9% of smokers, 2% of never-smokers, and 5% of patients with P16-positive oropharyngeal squamous cell carcinoma (OPSCC). Clinically suspicious PET-positive foci outside the head-neck were malignant in 55% of smokers, 34% of never-smokers, and in 38% of P16-pos OPSCC. All but two patients with cancer occurring outside the head and neck region were smokers. CONCLUSION: Malignancy outside the neck at diagnosis was more frequent in smokers compared to non-smokers or P16-pos OPSCC. A high proportion of clinically suspicious PET-positive foci were non-malignant.
PURPOSE: Whole-body FDG-PET-CT is widely used at diagnosis of squamous cell carcinoma of the head and neck (SCCHN) but may identify suspicious lesions outside the neck that require investigation. This study evaluated the impact of smoking and P16-status on the incidence of malignant disease outside the head and neck region in newly diagnosed patients with SCCHN. METHODS: All PET-positive foci outside the head-neck area were registered in 1069 patients planned for postoperative or curative intent radiotherapy with whole-body FDG-PET/CT from 2006 to 2012. All patient files were retrospectively investigated and clinical parameters, tobacco use, HPV (P16)-status and subsequent malignant disease registered. RESULTS: Malignancy outside the neck was diagnosed in 9% of smokers, 2% of never-smokers, and 5% of patients with P16-positive oropharyngeal squamous cell carcinoma (OPSCC). Clinically suspicious PET-positive foci outside the head-neck were malignant in 55% of smokers, 34% of never-smokers, and in 38% of P16-pos OPSCC. All but two patients with cancer occurring outside the head and neck region were smokers. CONCLUSION: Malignancy outside the neck at diagnosis was more frequent in smokers compared to non-smokers or P16-pos OPSCC. A high proportion of clinically suspicious PET-positive foci were non-malignant.
Authors: Amanda-Louise Fenger Carlander; Christian Grønhøj Larsen; David Hebbelstrup Jensen; Emilie Garnæs; Katalin Kiss; Luise Andersen; Caroline Holkmann Olsen; Maria Franzmann; Estrid Høgdall; Susanne K Kjær; Bodil Norrild; Lena Specht; Elo Andersen; Thomas van Overeem Hansen; Finn Cilius Nielsen; Christian von Buchwald Journal: Eur J Cancer Date: 2016-11-23 Impact factor: 9.162
Authors: Gianpiero Manca; Eleonora Vanzi; Domenico Rubello; Francesco Giammarile; Gaia Grassetto; Ka Kit Wong; Alan C Perkins; Patrick M Colletti; Duccio Volterrani Journal: Eur J Nucl Med Mol Imaging Date: 2016-01-19 Impact factor: 9.236
Authors: S Pedraza; A Ruiz-Alonso; A C Hernández-Martínez; E Cabello; D Lora; J F Pérez-Regadera Journal: Rev Esp Med Nucl Imagen Mol (Engl Ed) Date: 2019-01-14
Authors: Uliyana Yankevich; Marion A Hughes; Tanya J Rath; Saeed Fakhran; Lea M Alhilahi; Kim W Seungwon; Barton F Branstetter Journal: AJR Am J Roentgenol Date: 2017-02-08 Impact factor: 3.959
Authors: John S Beatty; Hadyn T Williams; Beau A Aldridge; Matthew P Hughes; Viren S Vasudeva; Angela L Gucwa; George S David; D Scott Lind; E James Kruse; James M McLoughlin Journal: Surgery Date: 2009-08 Impact factor: 3.982
Authors: H Kaida; M Ishibashi; S Kurata; Y Uchiyama; N Tanaka; T Abe; M Kobayashi; H Kaibara; M Uchida; T Nakashima; H Fujita; N Hayabuchi Journal: Nuklearmedizin Date: 2009-07-28 Impact factor: 1.379
Authors: Max Rohde; Anne L Nielsen; Jørgen Johansen; Jens A Sørensen; Nina Nguyen; Anabel Diaz; Mie K Nielsen; Jon T Asmussen; Janus M Christiansen; Oke Gerke; Anders Thomassen; Abass Alavi; Poul Flemming Høilund-Carlsen; Christian Godballe Journal: J Nucl Med Date: 2017-06-01 Impact factor: 10.057