Yuanyuan Guan1, Yang Hao2, Yun Guan3, Huaien Bu4, Hongwu Wang5. 1. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. 2. Department of Traditional Chinese Medicine, Tianjin First Central Hospital, Tianjin, 300270, China. 3. Crawford School of Public Policy, Asia and Pacific College, Australian National University, Canberra, ACT, 2601, Australia. 4. School of Health Sciences and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. buhuaien1976@163.com. 5. School of Health Sciences and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. tjwanghw5555@163.com.
Abstract
OBJECTIVE: Observational studies have shown that vitamin D levels are inversely related to ulcerative colitis activity, yet evidence from population interventions remains inconsistent. We conducted a systematic review and meta-analysis of randomized-controlled trials to clarify the effect of vitamin D on blood markers in patients with ulcerative colitis. METHODS: The PubMed, Cochrane Library, Embase, CNKI, VIP, and Wanfang databases were searched for studies published before June 2020. Information was collected regarding serum vitamin D levels, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), and Ca (calcium), and parathyroid hormone (PTH), and ulcerative colitis disease activity index (UCDAI) research data. RESULTS: Seven studies (n = 539) were included in the meta-analysis. Vitamin D supplementation resulted in significant improvements in the serum vitamin D levels (standardized mean difference (SMD) = 0.69, 95% CI (0.36, 1.03), P < 0.001), ESR (weighted mean difference (WMD) = - 1.10, 95% CI (- 1.97, - 0.24), P = 0.01), CRP (SMD = - 0.43, 95% CI (- 0.67, - 0.20), P = 0.0003), and Ca (SMD = 0.92, 95% CI (0.09, 1.74), P = 0.03) but not in other outcomes. According to subgroup analysis, supplementation with vitamin D at a dose of ≥ 300,000 IU/day can improve serum vitamin D levels. Supplementation with a sufficient dose of vitamin D in a short period of time can also improve serum vitamin D levels. According to GRADE method evaluation, the evidence quality was classified as low for the Serum Vitamin D Level and ESR, and very low for the CRP, PTH, Ca, and UCDAI. CONCLUSIONS: Compared with placebo control interventions, vitamin D supplementation seemed to be an effective intervention for patients with ulcerative colitis. Different doses of vitamin D and durations of intervention produce different effects. However, due to the limitation of the quality of the included studies, the above conclusions still need to be verified by more high-quality studies and weak clinical recommendations.
OBJECTIVE: Observational studies have shown that vitamin D levels are inversely related to ulcerative colitis activity, yet evidence from population interventions remains inconsistent. We conducted a systematic review and meta-analysis of randomized-controlled trials to clarify the effect of vitamin D on blood markers in patients with ulcerative colitis. METHODS: The PubMed, Cochrane Library, Embase, CNKI, VIP, and Wanfang databases were searched for studies published before June 2020. Information was collected regarding serum vitamin D levels, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), and Ca (calcium), and parathyroid hormone (PTH), and ulcerative colitis disease activity index (UCDAI) research data. RESULTS: Seven studies (n = 539) were included in the meta-analysis. Vitamin D supplementation resulted in significant improvements in the serum vitamin D levels (standardized mean difference (SMD) = 0.69, 95% CI (0.36, 1.03), P < 0.001), ESR (weighted mean difference (WMD) = - 1.10, 95% CI (- 1.97, - 0.24), P = 0.01), CRP (SMD = - 0.43, 95% CI (- 0.67, - 0.20), P = 0.0003), and Ca (SMD = 0.92, 95% CI (0.09, 1.74), P = 0.03) but not in other outcomes. According to subgroup analysis, supplementation with vitamin D at a dose of ≥ 300,000 IU/day can improve serum vitamin D levels. Supplementation with a sufficient dose of vitamin D in a short period of time can also improve serum vitamin D levels. According to GRADE method evaluation, the evidence quality was classified as low for the Serum Vitamin D Level and ESR, and very low for the CRP, PTH, Ca, and UCDAI. CONCLUSIONS: Compared with placebo control interventions, vitamin D supplementation seemed to be an effective intervention for patients with ulcerative colitis. Different doses of vitamin D and durations of intervention produce different effects. However, due to the limitation of the quality of the included studies, the above conclusions still need to be verified by more high-quality studies and weak clinical recommendations.
Authors: Pawel Pludowski; Michael F Holick; William B Grant; Jerzy Konstantynowicz; Mario R Mascarenhas; Afrozul Haq; Vladyslav Povoroznyuk; Nataliya Balatska; Ana Paula Barbosa; Tatiana Karonova; Ema Rudenka; Waldemar Misiorowski; Irina Zakharova; Alena Rudenka; Jacek Łukaszkiewicz; Ewa Marcinowska-Suchowierska; Natalia Łaszcz; Pawel Abramowicz; Harjit P Bhattoa; Sunil J Wimalawansa Journal: J Steroid Biochem Mol Biol Date: 2017-02-12 Impact factor: 4.292
Authors: Ola Olén; Rune Erichsen; Michael C Sachs; Lars Pedersen; Jonas Halfvarson; Johan Askling; Anders Ekbom; Henrik Toft Sørensen; Jonas F Ludvigsson Journal: Lancet Date: 2020-01-11 Impact factor: 79.321
Authors: Cedric F Garland; June Jiwon Kim; Sharif Burgette Mohr; Edward Doerr Gorham; William B Grant; Edward L Giovannucci; Leo Baggerly; Heather Hofflich; Joe Wesley Ramsdell; Kenneth Zeng; Robert P Heaney Journal: Am J Public Health Date: 2014-06-12 Impact factor: 9.308
Authors: Pawel Pludowski; Michael F Holick; Stefan Pilz; Carol L Wagner; Bruce W Hollis; William B Grant; Yehuda Shoenfeld; Elisabeth Lerchbaum; David J Llewellyn; Katharina Kienreich; Maya Soni Journal: Autoimmun Rev Date: 2013-03-28 Impact factor: 9.754
Authors: Jean-Claude Souberbielle; Jean-Jacques Body; Joan M Lappe; Mario Plebani; Yehuda Shoenfeld; Thomas J Wang; Heike A Bischoff-Ferrari; Etienne Cavalier; Peter R Ebeling; Patrice Fardellone; Sara Gandini; Damien Gruson; Alain P Guérin; Lene Heickendorff; Bruce W Hollis; Sofia Ish-Shalom; Guillaume Jean; Philipp von Landenberg; Alvaro Largura; Tomas Olsson; Charles Pierrot-Deseilligny; Stefan Pilz; Angela Tincani; Andre Valcour; Armin Zittermann Journal: Autoimmun Rev Date: 2010-07-01 Impact factor: 9.754
Authors: Siew C Ng; Hai Yun Shi; Nima Hamidi; Fox E Underwood; Whitney Tang; Eric I Benchimol; Remo Panaccione; Subrata Ghosh; Justin C Y Wu; Francis K L Chan; Joseph J Y Sung; Gilaad G Kaplan Journal: Lancet Date: 2017-10-16 Impact factor: 79.321