Angelo Nicosia1, Antonio Abbadessa1, Fabiana Vento1, Antonino Mazzaglia2, Placido Giuseppe Mineo1,3,4. 1. Department of Chemical Sciences and INSTM UdR of Catania, University of Catania, V.le A. Doria 6, 95125 Catania, Italy. 2. CNR-ISMN, Istituto per lo Studio dei Materiali Nanostrutturati, V. le F. Stagno d'Alcontres 31, 98166 Messina, Italy. 3. Institute for Chemical and Physical Processes CNR-IPCF, Viale F. Stagno d'Alcontres 37, 98158 Messina, Italy. 4. Institute of Polymers, Composites and Biomaterials CNR-IPCB, Via P. Gaifami 18, 95126 Catania, Italy.
Abstract
Silver nanoparticles (AgNPs) stand out over other metal nanoparticles thanks to their peculiar bactericidal and spectroscopic properties. Tunability of the AgNPs chemical-physical properties could be provided through their organic covalent coating. On the other hand, PEGylated porphyrin derivatives are versatile heteromacrocycles investigated for uses in the biomedical field as cytotoxic and tracking agents, but also as sensors. In this work, an easy multi-step approach was employed to produce coated silver nanoparticles. Specifically, the AgNPs were functionalized with 5,10,15-[p-(ω-methoxy-polyethyleneoxy)phenyl]-20-(p-hydroxyphenyl)-porphyrin (P(PEG350)3), using chloropropanethiol as a coupling agent. The P(PEG350)3 was structurally characterized through MALDI-TOF mass spectrometry, NMR spectroscopy and thermal analyses. The functionalization of AgNPs was monitored step-by-step employing UV-Vis spectroscopy, dynamic light scattering and thermogravimetric techniques. HRTEM and STEM measurements were used to investigate the morphology and the composition of the resulting nanostructured system (AgNP@P(PEG350)3), observing a long-range alignment of the outer porphyrin layer. The AgNP@P(PEG350)3 combines the features of the P(PEG350)3 with those of AgNPs, producing a potential multifunctional theranostic tool. The nanosystem revealed itself suitable as a removable pH sensor in aqueous solutions and potentially feasible for biological environment applications.
Silver nanpan>oparticles (pan> class="Chemical">AgNPs) stand out over other metal nanoparticles thanks to their peculiar bactericidal and spectroscopic properties. Tunability of the AgNPs chemical-physical properties could be provided through their organic covalent coating. On the other hand, PEGylated porphyrin derivatives are versatile heteromacrocycles investigated for uses in the biomedical field as cytotoxic and tracking agents, but also as sensors. In this work, an easy multi-step approach was employed to produce coated silver nanoparticles. Specifically, the AgNPs were functionalized with 5,10,15-[p-(ω-methoxy-polyethyleneoxy)phenyl]-20-(p-hydroxyphenyl)-porphyrin (P(PEG350)3), using chloropropanethiol as a coupling agent. The P(PEG350)3 was structurally characterized through MALDI-TOF mass spectrometry, NMR spectroscopy and thermal analyses. The functionalization of AgNPs was monitored step-by-step employing UV-Vis spectroscopy, dynamic light scattering and thermogravimetric techniques. HRTEM and STEM measurements were used to investigate the morphology and the composition of the resulting nanostructured system (AgNP@P(PEG350)3), observing a long-range alignment of the outer porphyrin layer. The AgNP@P(PEG350)3 combines the features of the P(PEG350)3 with those of AgNPs, producing a potential multifunctional theranostic tool. The nanosystem revealed itself suitable as a removable pH sensor in aqueous solutions and potentially feasible for biological environment applications.
Authors: Jose Ruben Morones; Jose Luis Elechiguerra; Alejandra Camacho; Katherine Holt; Juan B Kouri; Jose Tapia Ramírez; Miguel Jose Yacaman Journal: Nanotechnology Date: 2005-08-26 Impact factor: 3.874
Authors: Sanda C Boca; Monica Potara; Ana-Maria Gabudean; Aurelie Juhem; Patrice L Baldeck; Simion Astilean Journal: Cancer Lett Date: 2011-06-24 Impact factor: 8.679