Gianna Maria Nardi1, Roberta Grassi2, Artnora Ndokaj1, Michela Antonioni1, Maciej Jedlinski3, Gabriele Rumi4, Katarzyna Grocholewicz3, Irena Dus-Ilnicka5, Felice Roberto Grassi6, Livia Ottolenghi1, Marta Mazur1. 1. Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy. 2. Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy. 3. Department of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland. 4. Foundation Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy. 5. Department of Oral Pathology, Wroclaw Medical University, ul. Krakowska 26, 52-425 Wrocław, Poland. 6. Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, 70122 Bari, Italy.
Abstract
(1) Background: The purpose of the study was to comprehensively analyze the relationship between the mother's oral microbiome, modes of delivery and feeding, and the formation of the newborn child's oral microbiome. (2) Methods: This systematic review included a search through MEDLINE (PubMed) database (from 2010 to July 2020). Research was registered in PROSPERO under the number CRD42021241044. (3) Results: Of the 571 studies, 11 met the inclusion criteria. Included studies were classified according to (i) child's delivery mode, (ii) maternal exposure to antibiotics and disinfectants, and (iii) feeding type. (4) Conclusions: The interpretation of these papers shows that the type of delivery, maternal exposure to disinfectants and antibiotics during delivery, maternal health classed as overweight, gestational diabetes mellitus, and feeding type are correlated to changes in the maternal and neonatal early oral microbiomes, based on the analysis provided in this systematic review. Because no evidence exists regarding the impact of maternal diet and maternal oral health on the establishment and development of the early oral newborn microbiome, more studies are needed to deepen the knowledge and understanding of the subject and develop preventive and therapeutic strategies of support to pregnant women.
(1) Background: The purpose of the study was to comprehensively analyze the relationship between the mother's oral microbiome, modes of delivery and feeding, and the formation of the newborn child's oral microbiome. (2) Methods: This systematic review included a search through MEDLINE (PubMed) database (from 2010 to July 2020). Research was registered in PROSPERO under the number CRD42021241044. (3) Results: Of the 571 studies, 11 met the inclusion criteria. Included studies were classified according to (i) child's delivery mode, (ii) maternal exposure to antibiotics and disinfectants, and (iii) feeding type. (4) Conclusions: The interpretation of these papers shows that the type of delivery, maternal exposure to disinfectants and antibiotics during delivery, maternal health classed as overweight, gestational diabetes mellitus, and feeding type are correlated to changes in the maternal and neonatal early oral microbiomes, based on the analysis provided in this systematic review. Because no evidence exists regarding the impact of maternal diet and maternal oral health on the establishment and development of the early oral newborn microbiome, more studies are needed to deepen the knowledge and understanding of the subject and develop preventive and therapeutic strategies of support to pregnant women.
Entities:
Keywords:
antibiotics; breastfeeding; c-section; early life; newborn; one thousand days; oral health; oral microbiome; pregnancy; vaginal delivery
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