| Literature DB >> 34071007 |
Tom Wai-Hin Chung1, Hui Zhang2, Fergus Kai-Chuen Wong3, Siddharth Sridhar1,4,5, Kwok-Hung Chan1, Vincent Chi-Chung Cheng1, Kwok-Yung Yuen1,4,5,6, Ivan Fan-Ngai Hung4,7, Henry Ka-Fung Mak2,8,9.
Abstract
Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm3 to 49.5 mm3 (120%), left: 37.5 mm3 to 42 mm3 (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].Entities:
Keywords: COVID-19; olfactory dysfunction; resting-state fMRI; smell training; vitamin A
Year: 2021 PMID： 34071007 DOI： 10.3390/brainsci11060686
Source DB: PubMed Journal: Brain Sci ISSN： 2076-3425