Anita Raducka1, Agnieszka Czylkowska1, Katarzyna Gobis2, Kamila Czarnecka3,4, Paweł Szymański3,4, Marcin Świątkowski1. 1. Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland. 2. Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. Hallera 107, 80-416 Gdansk, Poland. 3. Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. 4. Department of Radiobiology and Radiation Protection, Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland.
Abstract
Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal-ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC50 (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown.
Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, n class="Disease">cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal-ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC50 (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown.
Authors: José María Sanchez-Pina; Mario Rodríguez Rodriguez; Nerea Castro Quismondo; Rodrigo Gil Manso; Rafael Colmenares; Daniel Gil Alos; Mari Liz Paciello; Denis Zafra; Cristina Garcia-Sanchez; Carolina Villegas; Clara Cuellar; Gonzalo Carreño-Tarragona; Irene Zamanillo; María Poza; Rodrigo Iñiguez; Xabier Gutierrez; Rafael Alonso; Antonia Rodríguez; Maria Dolores Folgueira; Rafael Delgado; José Miguel Ferrari; Manuel Lizasoain; José María Aguado; Rosa Ayala; Joaquín Martinez-Lopez; María Calbacho Journal: Eur J Haematol Date: 2020-08-11 Impact factor: 2.997
Authors: Abdulsalam A M Alkhaldi; Mohammad M Al-Sanea; Alessio Nocentini; Wagdy M Eldehna; Zainab M Elsayed; Alessandro Bonardi; Mahmoud F Abo-Ashour; Ashraf K El-Damasy; Mohammed S Abdel-Maksoud; Tarfah Al-Warhi; Paola Gratteri; Hatem A Abdel-Aziz; Claudiu T Supuran; Radwan El-Haggar Journal: Eur J Med Chem Date: 2020-08-22 Impact factor: 6.514
Authors: Tugce N Yigenoglu; Naim Ata; Fevzi Altuntas; Semih Bascı; Mehmet Sinan Dal; Serdal Korkmaz; Sinem Namdaroglu; Abdulkadir Basturk; Tuba Hacıbekiroglu; Mehmet H Dogu; İlhami Berber; Kursat Dal; Mehmet A Erkurt; Burhan Turgut; Mustafa Mahir Ulgu; Osman Celik; Ersan Imrat; Suayip Birinci Journal: J Med Virol Date: 2020-08-26 Impact factor: 20.693