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Literature DB >> 34070827

PDS5A and PDS5B in Cohesin Function and Human Disease.

Nenggang Zhang¹, Luiza E Coutinho¹, Debananda Pati¹.

Abstract

Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays important roles in various cellular processes, such as sister chromatid cohesion, DNA damage repair, gene transcription, and DNA replication. Vertebrates have two paralogs of PDS5, PDS5A and PDS5B, which have redundant and unique roles in regulating cohesin functions. Herein, we discuss the molecular characteristics and functions of PDS5, as well as the effects of its mutations in the development of diseases and their relevance for novel therapeutic strategies.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: PDS5A; PDS5B; cancer; cohesin; cohesinopathy

Year: 2021 PMID： 34070827 DOI： 10.3390/ijms22115868

Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923

180 in total

1. Pathways of DNA double-strand break repair during the mammalian cell cycle.

Authors: Kai Rothkamm; Ines Krüger; Larry H Thompson; Markus Löbrich
Journal: Mol Cell Biol Date: 2003-08 Impact factor: 4.272

2. Cohesins functionally associate with CTCF on mammalian chromosome arms.

Authors: Vania Parelho; Suzana Hadjur; Mikhail Spivakov; Marion Leleu; Stephan Sauer; Heather C Gregson; Adam Jarmuz; Claudia Canzonetta; Zoe Webster; Tatyana Nesterova; Bradley S Cobb; Kyoko Yokomori; Niall Dillon; Luis Aragon; Amanda G Fisher; Matthias Merkenschlager
Journal: Cell Date: 2008-01-31 Impact factor: 41.582

3. Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs.

Authors: Shunichi Kosugi; Masako Hasebe; Masaru Tomita; Hiroshi Yanagawa
Journal: Proc Natl Acad Sci U S A Date: 2009-06-11 Impact factor: 11.205

4. Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA.

Authors: Mai Kanke; Eri Tahara; Pim J Huis In't Veld; Tomoko Nishiyama
Journal: EMBO J Date: 2016-11-21 Impact factor: 11.598

5. de Lange syndrome: a clinical review of 310 individuals.

Authors: L Jackson; A D Kline; M A Barr; S Koch
Journal: Am J Med Genet Date: 1993-11-15

Review 6. The ancient and evolving roles of cohesin in gene expression and DNA repair.

Authors: Dale Dorsett; Lena Ström
Journal: Curr Biol Date: 2012-04-10 Impact factor: 10.834

7. Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.

Authors: James Lightfoot; Sarah Testori; Consuelo Barroso; Enrique Martinez-Perez
Journal: Curr Biol Date: 2011-09-13 Impact factor: 10.834

8. Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis.

Authors: Hui Jin; Vincent Guacci; Hong-Guo Yu
Journal: J Cell Biol Date: 2009-09-07 Impact factor: 10.539

9. Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

Authors: Erez Lieberman-Aiden; Nynke L van Berkum; Louise Williams; Maxim Imakaev; Tobias Ragoczy; Agnes Telling; Ido Amit; Bryan R Lajoie; Peter J Sabo; Michael O Dorschner; Richard Sandstrom; Bradley Bernstein; M A Bender; Mark Groudine; Andreas Gnirke; John Stamatoyannopoulos; Leonid A Mirny; Eric S Lander; Job Dekker
Journal: Science Date: 2009-10-09 Impact factor: 47.728

PDS5A and PDS5B in Cohesin Function and Human Disease.

1. Pathways of DNA double-strand break repair during the mammalian cell cycle.

2. Cohesins functionally associate with CTCF on mammalian chromosome arms.

3. Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs.

4. Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA.

5. de Lange syndrome: a clinical review of 310 individuals.

Review 6. The ancient and evolving roles of cohesin in gene expression and DNA repair.

7. Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.

8. Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis.

9. Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

10. MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm.

Review 1. The Interplay of Cohesin and RNA Processing Factors: The Impact of Their Alterations on Genome Stability.

Review 2. 3D chromatin architecture and transcription regulation in cancer.

3. Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.

4. 1-L Transcription in Alzheimer's Disease.

5. S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.

6. A cohesin-associated gene score may predict immune checkpoint blockade in hepatocellular carcinoma.