Literature DB >> 3406362

Benzamide-inhibitable alterations in spectral properties of chromatin accompany DNA repair in UVC-exposed L5178Y cells.

H E Kleczkowska1, I Buraczewska, I Szumiel.   

Abstract

We examined the response of chromatin to increasing NaCl and MgCl2 concentrations in UVC-irradiated L5178Y (LY) R and S cells, using the spectral index method (Dixon and Burkholder 1985). We have found an alteration in chromatin properties 1 h after UVC-irradiation of repair proficient LY-S cells, but no change in repair deficient LY-R cells. The change was shown as lowered spectral index, indicating that at given Na+ and Mg++ concentrations (1 or 200 mM NaCl, 0 or 0.5 mM MgCl2) chromatin from UVC-irradiated LY-S cells was more compact than that from unirradiated ones. Benzamide treatment reversed the effect of UVC-irradiation in LY-S cells and did not change the response pattern of chromatin from LY-R cells or unirradiated LY-S cells.

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Year:  1988        PMID： 3406362     DOI： 10.1007/bf01210838

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN： 0301-634X            Impact factor:   1.925


  14 in total

1.  Mouse lymphoma cells with different radiosensitivities.

Authors:  P ALEXANDER
Journal:  Nature       Date:  1961-11-11       Impact factor: 49.962

2.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

3.  The repair of double-strand DNA breaks correlates with radiosensitivity of L5178Y-S and L5178Y-R cells.

Authors:  D Wlodek; W N Hittelman
Journal:  Radiat Res       Date:  1987-10       Impact factor: 2.841

4.  Periodic changes of chromatin organization associated with rearrangement of repair patches accompany DNA excision repair of mammalian cells.

Authors:  G Mathis; F R Althaus
Journal:  J Biol Chem       Date:  1986-05-05       Impact factor: 5.157

5.  Impaired repair of UVC-induced DNA damage in L5178Y-R cells: DNA unwinding studies with the use of 1-beta-D-arabinofuranosyl cytosine.

Authors:  I Szumiel; D Wlodek; K J Johanson
Journal:  Photochem Photobiol       Date:  1988-08       Impact factor: 3.421

6.  Eukaryotic DNA repair is blocked at different steps by inhibitors of DNA topoisomerases and of DNA polymerases alpha and beta.

Authors:  M R Mattern; R F Paone; R S Day
Journal:  Biochim Biophys Acta       Date:  1982-04-26

7.  The effects of sodium and magnesium-ion interactions on chromatin structure and solubility.

Authors:  D K Dixon; G D Burkholder
Journal:  Eur J Cell Biol       Date:  1985-03       Impact factor: 4.492

8.  Characterization of deoxyribonucleic acid synthesis in reconstituted nuclear systems.

Authors:  T Enomoto; S Tanuma; M Yamada
Journal:  Biochemistry       Date:  1983-03-01       Impact factor: 3.162

9.  Response of two strains of L5178Y cells to cis-dichlorobis(cyclopentylamine)platinum(II). I. Cross-sensitivity to cis-PAD and UV light.

Authors:  I Szumiel
Journal:  Chem Biol Interact       Date:  1979-01       Impact factor: 5.192

10.  Loss of tumorigenicity with simultaneous changes in radiosensitivity and photosensitivity during in vitro growth of L5178Y murine lymphoma cells.

Authors:  J Z Beer; E Budzicka; E Niepokojczycka; O Rosiek; I Szumiel; M Walicka
Journal:  Cancer Res       Date:  1983-10       Impact factor: 12.701
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