Pierre-Yves Charles1,2, Marion Vallet1,2, Renaud De La Faille3, Pierre Merville3, Séverine Lagarde4, Nicolas Grenier5, Claire Lebely1, Benoît Lepage6, Julien Allard1, Nassim Kamar7, Ivan Tack8,9,10. 1. Explorations Fonctionnelles Physiologiques, Hôpital Rangueil, CHU de Toulouse, Toulouse, France. 2. Laboratoire de Physiologie, Facultés de médecine, Université Paul Sabatier, Toulouse, France. 3. Service de Néphrologie, Transplantation rénale, Dialyse, Aphérèse, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 4. Service de Radiologie, Hôpital Rangueil, CHU de Toulouse, Toulouse, France. 5. Service d'Imagerie Médicale, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 6. Département Universitaire d'Epidémiologie, Economie de la Santé et Santé Publique, CHU de Toulouse, Toulouse, France. 7. Néphrologie et transplantation d'organe, Hôpital Rangueil, CHU de Toulouse, Toulouse, France. 8. Explorations Fonctionnelles Physiologiques, Hôpital Rangueil, CHU de Toulouse, Toulouse, France. ivan.tack@univ-tlse3.fr. 9. Laboratoire de Physiologie, Facultés de médecine, Université Paul Sabatier, Toulouse, France. ivan.tack@univ-tlse3.fr. 10. Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institute of Cardiovascular and Metabolic Disease, Université Toulouse III Paul-Sabatier, Toulouse, France. ivan.tack@univ-tlse3.fr.
Abstract
INTRODUCTION: Although living kidney donation is not a high-risk surgery, there is still a need to identify situations at risk of kidney disease after uninephrectomy. Estrogens exhibit a protective role against various nephropathies. The aim of this study was to assess renal adaptation following nephrectomy according to menopausal status in women. METHODS: A prospective bicentric study including living women donors measured glomerular filtration rate (GFR) (inulin or 51-Cr-EDTA clearances) and kidney volume (using CT-scan and 3-dimensional reconstruction), before and after 1-year post-uninephrectomy. Renal adaptation was compared according to menopausal status. RESULTS: Sixteen non-menopausal women and 18 menopausal women were included. One year following uninephrectomy, the mean decrease in GFR (global population) was - 32 ± 12 ml/min/1.73 m2, and the mean increase in remnant kidney volume was + 32 ± 13 cm3/1.73 m2. No significant difference was observed between the two groups for both the decrease in GFR (-32.9 ± 13.3 in non-menopausal vs - 31.5 ± 9.9 in menopausal, ml/min/1.73 m2, p = 0.84), and the increase in kidney volume (+ 36.1 ± 13.4 in non-menopausal vs + 28.1 ± 12.5 in menopausal, cm3/1.73 m2, p = 0.09). DISCUSSION: Menopausal status did not influence kidney adaptation following uninephrectomy, and in this respect is not a potential limiting factor for living kidney donation.
INTRODUCTION: Although living kidney donation is not a high-risk surgery, there is still a need to identify situations at risk of kidney disease after uninephrectomy. Estrogens exhibit a protective role against various nephropathies. The aim of this study was to assess renal adaptation following nephrectomy according to menopausal status in women. METHODS: A prospective bicentric study including living women donors measured glomerular filtration rate (GFR) (inulin or 51-Cr-EDTA clearances) and kidney volume (using CT-scan and 3-dimensional reconstruction), before and after 1-year post-uninephrectomy. Renal adaptation was compared according to menopausal status. RESULTS: Sixteen non-menopausal women and 18 menopausal women were included. One year following uninephrectomy, the mean decrease in GFR (global population) was - 32 ± 12 ml/min/1.73 m2, and the mean increase in remnant kidney volume was + 32 ± 13 cm3/1.73 m2. No significant difference was observed between the two groups for both the decrease in GFR (-32.9 ± 13.3 in non-menopausal vs - 31.5 ± 9.9 in menopausal, ml/min/1.73 m2, p = 0.84), and the increase in kidney volume (+ 36.1 ± 13.4 in non-menopausal vs + 28.1 ± 12.5 in menopausal, cm3/1.73 m2, p = 0.09). DISCUSSION: Menopausal status did not influence kidney adaptation following uninephrectomy, and in this respect is not a potential limiting factor for living kidney donation.
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