Literature DB >> 34060610

New insights into promoter-enhancer communication mechanisms revealed by dynamic single-molecule imaging.

Jieru Li1, Alexandros Pertsinidis1.   

Abstract

Establishing cell-type-specific gene expression programs relies on the action of distal enhancers, cis-regulatory elements that can activate target genes over large genomic distances - up to Mega-bases away. How distal enhancers physically relay regulatory information to target promoters has remained a mystery. Here, we review the latest developments and insights into promoter-enhancer communication mechanisms revealed by live-cell, real-time single-molecule imaging approaches.
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Entities:  

Keywords:  enhancers; genome organization; optical nanoscopy; single-molecule approaches; transcription

Mesh：

Substances：

Year:  2021        PMID： 34060610      PMCID： PMC8325597          DOI： 10.1042/BST20200963

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   4.919


  77 in total

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Authors:  Ibrahim I Cisse; Ignacio Izeddin; Sebastien Z Causse; Lydia Boudarene; Adrien Senecal; Leila Muresan; Claire Dugast-Darzacq; Bassam Hajj; Maxime Dahan; Xavier Darzacq
Journal:  Science       Date:  2013-07-04       Impact factor: 47.728

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Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-08       Impact factor: 11.205

3.  Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly.

Authors:  Sreejith J Nair; Lu Yang; Dario Meluzzi; Soohwan Oh; Feng Yang; Meyer J Friedman; Susan Wang; Tom Suter; Ibraheem Alshareedah; Amir Gamliel; Qi Ma; Jie Zhang; Yiren Hu; Yuliang Tan; Kenneth A Ohgi; Ranveer Singh Jayani; Priya R Banerjee; Aneel K Aggarwal; Michael G Rosenfeld
Journal:  Nat Struct Mol Biol       Date:  2019-03-04       Impact factor: 15.369

4.  YY1 Is a Structural Regulator of Enhancer-Promoter Loops.

Authors:  Abraham S Weintraub; Charles H Li; Alicia V Zamudio; Alla A Sigova; Nancy M Hannett; Daniel S Day; Brian J Abraham; Malkiel A Cohen; Behnam Nabet; Dennis L Buckley; Yang Eric Guo; Denes Hnisz; Rudolf Jaenisch; James E Bradner; Nathanael S Gray; Richard A Young
Journal:  Cell       Date:  2017-12-07       Impact factor: 41.582

5.  Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity.

Authors:  Jeffrey M Alexander; Juan Guan; Bingkun Li; Lenka Maliskova; Michael Song; Yin Shen; Bo Huang; Stavros Lomvardas; Orion D Weiner
Journal:  Elife       Date:  2019-05-24       Impact factor: 8.140

6.  Active RNA polymerases are localized within discrete transcription "factories' in human nuclei.

Authors:  F J Iborra; A Pombo; D A Jackson; P R Cook
Journal:  J Cell Sci       Date:  1996-06       Impact factor: 5.285

7.  3D imaging of Sox2 enhancer clusters in embryonic stem cells.

Authors:  Zhe Liu; Wesley R Legant; Bi-Chang Chen; Li Li; Jonathan B Grimm; Luke D Lavis; Eric Betzig; Robert Tjian
Journal:  Elife       Date:  2014-12-24       Impact factor: 8.140

8.  Dense Bicoid hubs accentuate binding along the morphogen gradient.

Authors:  Mustafa Mir; Armando Reimer; Jenna E Haines; Xiao-Yong Li; Michael Stadler; Hernan Garcia; Michael B Eisen; Xavier Darzacq
Journal:  Genes Dev       Date:  2017-09-01       Impact factor: 11.361

9.  Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus.

Authors:  B van Steensel; M Brink; K van der Meulen; E P van Binnendijk; D G Wansink; L de Jong; E R de Kloet; R van Driel
Journal:  J Cell Sci       Date:  1995-09       Impact factor: 5.285

10.  Single-gene imaging links genome topology, promoter-enhancer communication and transcription control.

Authors:  Jieru Li; Angela Hsu; Yujing Hua; Guanshi Wang; Lingling Cheng; Hiroshi Ochiai; Takashi Yamamoto; Alexandros Pertsinidis
Journal:  Nat Struct Mol Biol       Date:  2020-09-21       Impact factor: 15.369
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  1 in total

Review 1.  New insights into genome folding by loop extrusion from inducible degron technologies.

Authors:  Elzo de Wit; Elphège P Nora
Journal:  Nat Rev Genet       Date:  2022-09-30       Impact factor: 59.581
  1 in total

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