Literature DB >> 34056935

A Conditional Generative Adversarial Network for Synthesis of Continuous Glucose Monitoring Signals.

Simon Lebech Cichosz1, Alexander Arndt Pasgaard Xylander1.   

Abstract

This report describes how a Conditional Generative Adversarial Network (CGAN) was used to synthesize realistic continuous glucose monitoring systems (CGM) from healthy individuals and individuals with type 1 diabetes over a range of different HbA1c levels. The results showed that even though the CGAN generated data, did not perfectly reflect real world CGM, many of the important features were captured and reflected in the synthetic signals. It is briefly discussed how heterogenous data sources constitutes a challenge for comparison of predictive CGM models. Therefore 40,000 CGM days were generated by the trained CGAN, equivalent to 940,000 hours of synthetic CGM measurements. These data have been made available in a public database, which can be used as a reference in future studies.

Entities:  

Keywords:  CGM; artificial intelligence; generative adversarial networks; type 1 diabetes

Mesh:

Substances:

Year:  2021        PMID: 34056935      PMCID: PMC9445350          DOI: 10.1177/19322968211014255

Source DB:  PubMed          Journal:  J Diabetes Sci Technol        ISSN: 1932-2968


  16 in total

1.  Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial.

Authors:  Curt L Rohlfing; Hsiao-Mei Wiedmeyer; Randie R Little; Jack D England; Alethea Tennill; David E Goldstein
Journal:  Diabetes Care       Date:  2002-02       Impact factor: 19.112

2.  Validation in prediction research: the waste by data splitting.

Authors:  Ewout W Steyerberg
Journal:  J Clin Epidemiol       Date:  2018-07-29       Impact factor: 6.437

3.  The effect of real-time continuous glucose monitoring on glycemic control in patients with type 2 diabetes mellitus.

Authors:  Nicole M Ehrhardt; Mary Chellappa; M Susan Walker; Stephanie J Fonda; Robert A Vigersky
Journal:  J Diabetes Sci Technol       Date:  2011-05-01

4.  Combining information of autonomic modulation and CGM measurements enables prediction and improves detection of spontaneous hypoglycemic events.

Authors:  Simon Lebech Cichosz; Jan Frystyk; Lise Tarnow; Jesper Fleischer
Journal:  J Diabetes Sci Technol       Date:  2014-09-12

5.  Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study.

Authors:  Viral N Shah; Stephanie N DuBose; Zoey Li; Roy W Beck; Anne L Peters; Ruth S Weinstock; Davida Kruger; Michael Tansey; David Sparling; Stephanie Woerner; Francesco Vendrame; Richard Bergenstal; William V Tamborlane; Sara E Watson; Jennifer Sherr
Journal:  J Clin Endocrinol Metab       Date:  2019-10-01       Impact factor: 5.958

6.  Comment on Lachin et al. Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial. Diabetes Care 2017;40:777-783.

Authors:  Jesper Fleischer; Simon Lebech Cichosz; Troels Krarup Hansen
Journal:  Diabetes Care       Date:  2017-11       Impact factor: 19.112

7.  Risk Factors Associated With Severe Hypoglycemia in Older Adults With Type 1 Diabetes.

Authors:  Ruth S Weinstock; Stephanie N DuBose; Richard M Bergenstal; Naomi S Chaytor; Christina Peterson; Beth A Olson; Medha N Munshi; Alysa J S Perrin; Kellee M Miller; Roy W Beck; David R Liljenquist; Grazia Aleppo; John B Buse; Davida Kruger; Anuj Bhargava; Robin S Goland; Rachel C Edelen; Richard E Pratley; Anne L Peters; Henry Rodriguez; Andrew J Ahmann; John-Paul Lock; Satish K Garg; Michael R Rickels; Irl B Hirsch
Journal:  Diabetes Care       Date:  2015-12-17       Impact factor: 19.112

8.  A novel approach to continuous glucose analysis utilizing glycemic variation.

Authors:  C M McDonnell; S M Donath; S I Vidmar; G A Werther; F J Cameron
Journal:  Diabetes Technol Ther       Date:  2005-04       Impact factor: 6.118

Review 9.  Data-driven modeling and prediction of blood glucose dynamics: Machine learning applications in type 1 diabetes.

Authors:  Ashenafi Zebene Woldaregay; Eirik Årsand; Ståle Walderhaug; David Albers; Lena Mamykina; Taxiarchis Botsis; Gunnar Hartvigsen
Journal:  Artif Intell Med       Date:  2019-07-26       Impact factor: 5.326

10.  REPLACE-BG: A Randomized Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults With Well-Controlled Type 1 Diabetes.

Authors:  Grazia Aleppo; Katrina J Ruedy; Tonya D Riddlesworth; Davida F Kruger; Anne L Peters; Irl Hirsch; Richard M Bergenstal; Elena Toschi; Andrew J Ahmann; Viral N Shah; Michael R Rickels; Bruce W Bode; Athena Philis-Tsimikas; Rodica Pop-Busui; Henry Rodriguez; Emily Eyth; Anuj Bhargava; Craig Kollman; Roy W Beck
Journal:  Diabetes Care       Date:  2017-02-16       Impact factor: 19.112

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