Literature DB >> 34055217

Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules.

Xiaona Li1, Zirui Lü1, Cong Wang1, Kebin Li1, Fengrong Xu1, Ping Xu1, Yan Niu1.   

Abstract

The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of degraders of glutathione transferases and demonstrated them potently inducing apoptosis in cancer cells, presenting their pharmacological potential in cancer therapy.
© 2021 American Chemical Society.

Entities:  

Year:  2021        PMID： 34055217      PMCID： PMC8155291          DOI： 10.1021/acsmedchemlett.0c00627

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  23 in total

1.  Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals.

Authors:  Y Wu; Y Fan; B Xue; L Luo; J Shen; S Zhang; Y Jiang; Z Yin
Journal:  Oncogene       Date:  2006-04-24       Impact factor: 9.867

Review 2.  The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases.

Authors:  S Mahajan; W M Atkins
Journal:  Cell Mol Life Sci       Date:  2005-06       Impact factor: 9.261

3.  Human GSTA1-1 reduces c-Jun N-terminal kinase signalling and apoptosis in Caco-2 cells.

Authors:  Laura Romero; Kimberly Andrews; Lorraine Ng; Kelly O'Rourke; Ann Maslen; Gordon Kirby
Journal:  Biochem J       Date:  2006-11-15       Impact factor: 3.857

Review 4.  Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification.

Authors:  Kenneth D Tew; Danyelle M Townsend
Journal:  Drug Metab Rev       Date:  2011-02-25       Impact factor: 4.518

5.  Inhibitor mediated protein degradation.

Authors:  Marcus J C Long; Deviprasad R Gollapalli; Lizbeth Hedstrom
Journal:  Chem Biol       Date:  2012-05-25

6.  Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide.

Authors:  N Ban; Y Takahashi; T Takayama; T Kura; T Katahira; S Sakamaki; Y Niitsu
Journal:  Cancer Res       Date:  1996-08-01       Impact factor: 12.701

7.  Regulation of JNK signaling by GSTp.

Authors:  V Adler; Z Yin; S Y Fuchs; M Benezra; L Rosario; K D Tew; M R Pincus; M Sardana; C J Henderson; C R Wolf; R J Davis; Z Ronai
Journal:  EMBO J       Date:  1999-03-01       Impact factor: 11.598

8.  A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action.

Authors:  Serge Mignani; Nabil El Brahmi; Saïd El Kazzouli; Laure Eloy; Delphine Courilleau; Joachim Caron; Mosto M Bousmina; Anne-Marie Caminade; Thierry Cresteil; Jean-Pierre Majoral
Journal:  Eur J Med Chem       Date:  2016-06-11       Impact factor: 6.514

Review 9.  Glutathione S-transferases: an overview in cancer research.

Authors:  Giuliano Di Pietro; Luiz Alexandre V Magno; Fabrício Rios-Santos
Journal:  Expert Opin Drug Metab Toxicol       Date:  2010-02       Impact factor: 4.481

Review 10.  Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors.

Authors:  Marija Pljesa-Ercegovac; Ana Savic-Radojevic; Marija Matic; Vesna Coric; Tatjana Djukic; Tanja Radic; Tatjana Simic
Journal:  Int J Mol Sci       Date:  2018-11-28       Impact factor: 5.923
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