Literature DB >> 34055204

Dual Targeting of Function-Structure for Effective Killing of Pathogenic Free-Living Amoebae.

Ruqaiyyah Siddiqui1, Mohamed Yehia Abouleish1, Mustafa Khamis1, Taleb Ibrahim1, Naveed Ahmed Khan2.   

Abstract

Here we discuss the potential value of targeting both the hardy structure of the cyst state of the parasite, in addition to the active trophozoite form, to provide target-directed inhibition as a viable drug strategy in the effective eradication of parasites.
© 2021 American Chemical Society.

Entities:  

Year:  2021        PMID： 34055204      PMCID： PMC8155231          DOI： 10.1021/acsmedchemlett.1c00200

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  10 in total

1.  Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida.

Authors:  A Ahmad; A Khan; F Akhtar; S Yousuf; I Xess; L A Khan; N Manzoor
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-09-11       Impact factor: 3.267

2.  Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans.

Authors:  María Dolores Navarro-Martínez; Francisco García-Cánovas; José Neptuno Rodríguez-López
Journal:  J Antimicrob Chemother       Date:  2006-04-03       Impact factor: 5.790

Review 3.  Opportunistic amoebae: challenges in prophylaxis and treatment.

Authors:  Frederick L Schuster; Govinda S Visvesvara
Journal:  Drug Resist Updat       Date:  2004-02       Impact factor: 18.500

4.  Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida.

Authors:  Aijaz Ahmad; Amber Khan; Nikhat Manzoor; Luqman A Khan
Journal:  Microb Pathog       Date:  2009-10-14       Impact factor: 3.738

5.  Carbohydrate analysis of Acanthamoeba castellanii.

Authors:  Ricky Dudley; Edward L Jarroll; Naveed Ahmed Khan
Journal:  Exp Parasitol       Date:  2009-04-21       Impact factor: 2.011

6.  The cyst wall carbohydrate composition of Balamuthia mandrillaris.

Authors:  Ruqaiyyah Siddiqui; Naveed Ahmed Khan; Edward L Jarroll
Journal:  Parasitol Res       Date:  2009-02-12       Impact factor: 2.289

Review 7.  Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea.

Authors:  Govinda S Visvesvara; Hercules Moura; Frederick L Schuster
Journal:  FEMS Immunol Med Microbiol       Date:  2007-04-11

8.  Evaluation of Antifungal Activity and Mechanism of Action of Citral against Candida albicans.

Authors:  Maria Clerya Alvino Leite; André Parente de Brito Bezerra; Janiere Pereira de Sousa; Felipe Queiroga Sarmento Guerra; Edeltrudes de Oliveira Lima
Journal:  Evid Based Complement Alternat Med       Date:  2014-08-28       Impact factor: 2.629

9.  Galactose as novel target against Acanthamoeba cysts.

Authors:  Ayaz Anwar; Naveed A Khan; Ruqaiyyah Siddiqui
Journal:  PLoS Negl Trop Dis       Date:  2019-07-26

10.  Small molecules inhibit growth, viability and ergosterol biosynthesis in Candida albicans.

Authors:  Sandeep B Rajput; S Mohan Karuppayil
Journal:  Springerplus       Date:  2013-01-29
  10 in total

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