Literature DB >> 34054387

Non-Healing Burn Wound Treatment With A Sterile Silicone Gel.

E Lucattelli1, F Cipriani2, C Pascone2, A Di Lonardo2.   

Abstract

Treatment of burn wounds can be complicated due to fluid and electrolyte loss and the increased chance of infectious complications. Silicone-based products have become increasingly used for non-healing wound treatment, but no study has specifically addressed its potential on burn patients. The purpose of this study was to compare the use of sterile silicone gel with conventional medication in improving the healing of burn wounds. Between November 2019 and March 2020, 12 patients with mid-deep and deep burn wounds were included in the present study (average TBSA approximately 29%, range 13-51%). Patient average age was 49 years (range 29-67 years), 7 were male. In each patient two clinically similar areas were identified and treated every 48 hours with topical application of silicone gel in the form of Stratamed® (Group 1) and conventional medication (Group 2). All the cases healed without requiring skin grafting. No secondary wound infection nor allergic reactions were found. The mean days from commencing the treatment to 95% re-epithelialization in Groups 1 and 2 were 5.4 and 12.5, respectively. Culture samples were negative for common pathogens. Silicone gel has shown to be particularly effective in speeding up the re-epithelialization process. The protective film formed by the silicone helps to reduce possible infectious complications. Finally, silicone gel is easy to apply and associated with greater pain control during medication.
Copyright © 2021 Euro-Mediterranean Council for Burns and Fire Disasters.

Entities:  

Keywords:  burns; dressing; non-healing; secondary intention; silicone

Year:  2021        PMID: 34054387      PMCID: PMC8126373     

Source DB:  PubMed          Journal:  Ann Burns Fire Disasters        ISSN: 1592-9558


  13 in total

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5.  Permeability barrier function of skin exposed to ionizing radiation.

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6.  The safety, efficacy, and tolerability of a novel silicone gel dressing following dermatological surgery.

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Review 7.  Evolution of silicone therapy and mechanism of action in scar management.

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8.  An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor.

Authors:  Ceren Alemdaroğlu; Zelihagül Değim; Nevin Celebi; Fatih Zor; Serdar Oztürk; Deniz Erdoğan
Journal:  Burns       Date:  2006-03-09       Impact factor: 2.744

9.  The effect of silicone gel on basic fibroblast growth factor levels in fibroblast cell culture.

Authors:  Matthew M Hanasono; Joanne Lum; Lisa A Carroll; Anthony A Mikulec; R James Koch
Journal:  Arch Facial Plast Surg       Date:  2004 Mar-Apr

Review 10.  Skin tissue regeneration for burn injury.

Authors:  Anastasia Shpichka; Denis Butnaru; Evgeny A Bezrukov; Roman B Sukhanov; Anthony Atala; Vitaliy Burdukovskii; Yuanyuan Zhang; Peter Timashev
Journal:  Stem Cell Res Ther       Date:  2019-03-15       Impact factor: 6.832

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  1 in total

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  1 in total

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