Literature DB >> 3405376

Neurohormonal regulation of calcium in the cell.

A A Galoyan1, G A Kevorkian, L H Voskanian, S S Alexanian, M S Muradian.   

Abstract

Neurohormone C (NC) is a glycopeptide isolated from bovine hypothalamus, which inhibits Ca-calmodulin (CaM)-dependent cAMP and cGMP phosphodiesterase (PDE) and is a regulator of Ca in the cell. Distribution of [45Ca]CaCl2 in the mitochondria and reticulum (SR) of heart and brain mitochondria and changes of Ca-binding proteins in these organelles under NC influence have been studied in the myocardium before and after isoproterenol-induced necrosis. Intraperitoneal administration of 80-100 mU of PDE inhibitory activity of NC to rats did not cause any noticeable changes in the protein content of intracellular organelles, but altered the affinity of certain proteins to 45Ca2+. This property of NC was especially noticeable after isoproterenol necrosis. Necrotic injury of the myocardium induced Ca2+ storage in the mitochondria and SR of brain, and decreased the Ca2+ concentration in myocardial mitochondria. NC injection to the animals with necrosis was followed by Ca2+ release from all the studied organelles.

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Year:  1988        PMID： 3405376     DOI： 10.1007/bf01268886

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  14 in total

1.  Calmodulin stimulates human platelet phospholipase A2.

Authors:  P Y Wong; W Y Cheung
Journal:  Biochem Biophys Res Commun       Date:  1979-09-27       Impact factor: 3.575

2.  Phosphodiesterase protein activator stimulates calcium transport in cardiac microsomal preparations enriched in sarcoplasmic reticulum.

Authors:  S Katz; M A Remtulla
Journal:  Biochem Biophys Res Commun       Date:  1978-08-29       Impact factor: 3.575

3.  Protein activator of cyclic 3':5'-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase.

Authors:  W Y Cheung; L S Bradham; T J Lynch; Y M Lin; E A Tallant
Journal:  Biochem Biophys Res Commun       Date:  1975-10-06       Impact factor: 3.575

4.  Modulator protein as a component of the myosin light chain kinase from chicken gizzard.

Authors:  R Dabrowska; J M Sherry; D K Aromatorio; D J Hartshorne
Journal:  Biochemistry       Date:  1978-01-24       Impact factor: 3.162

Review 5.  Protein kinases.

Authors:  E G Krebs
Journal:  Curr Top Cell Regul       Date:  1972

6.  Isolation of sarcoplasmic reticulum by zonal centrifugation and purification of Ca 2+ -pump and Ca 2+ -binding proteins.

Authors:  G Meissner; G E Conner; S Fleischer
Journal:  Biochim Biophys Acta       Date:  1973-03-16

7.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

8.  A calcium/calmodulin-dependent protein kinase from mammalian brain that phosphorylates Synapsin I: partial purification and characterization.

Authors:  M B Kennedy; T McGuinness; P Greengard
Journal:  J Neurosci       Date:  1983-04       Impact factor: 6.167

9.  Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+.

Authors:  J G McCormack; R M Denton
Journal:  Biochem J       Date:  1984-02-15       Impact factor: 3.857

10.  Increased Ca2+ binding by a cardiac cell membrane preparation after cyclic AMP-enhanced intrinsic membrane protein phosphorylation.

Authors:  H Will; B Schirpke; A Wollenberger
Journal:  Recent Adv Stud Cardiac Struct Metab       Date:  1976
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