| Literature DB >> 34053060 |
Federica Rascio1, Paola Pontrelli2, Giuseppe Grandaliano3,4.
Abstract
Involvement of T lymphocytes in kidney transplantation is a well-developed topic; however, most of the scientific interest focused on the different type of CD4+ lymphocyte subpopulations. Few authors, instead, investigated the role of CD8+ T cells in renal transplantation and how deleterious they can be to long-term allograft survival. Recently, there has been a renewed interest in the CD8+ T cells involvement in the transplantation field with the aim to investigate the immunological mechanisms underlying the infiltration of CD8+ T cells and their biological functions in human kidney allografts. The purpose of the present review is to highlight the role of allo-reactive cytotoxic T lymphocytes (CTLs) CD8+ subset in allograft kidney recipients and their related clinical complications.Entities:
Keywords: Adaptive immunity; Cytokines; Cytotoxic T lymphocytes (CTLs); Cytotoxic-associated transcripts (CATs); Immunosuppression; Kidney transplantation; Rejection
Year: 2021 PMID: 34053060 DOI: 10.1007/978-1-0716-1507-2_14
Source DB: PubMed Journal: Methods Mol Biol ISSN: 1064-3745