Literature DB >> 3405240

Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria.

G Uziel1, B Garavaglia, S Di Donato.   

Abstract

L-carnitine stimulated CO2 production from 1-14C pyruvate in mitochondria from human skeletal muscle nearly twofold. A comparable increase in the pyruvate dehydrogenase complex (PDHC) activity was seen. Moreover, in the presence of L-carnitine and at pyruvate concentration greater than 0.25 mM, this effect was associated with a marked increase of acetylcarnitine synthesis. Deoxycarnitine, an inhibitor of carnitine acetyltransferase (CAT), partially reversed the effect of carnitine on PDHC activity. The stimulatory effect of carnitine on PDHC activity in human mitochondria is mediated by the modulation of the intramitochondrial acetyl-CoA/CoASH ratio.

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Year:  1988        PMID： 3405240     DOI： 10.1002/mus.880110708

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN： 0148-639X            Impact factor:   3.217


  26 in total

1.  Influence of L-carnitine administration on maximal physical exercise.

Authors:  L Vecchiet; F Di Lisa; G Pieralisi; P Ripari; R Menabò; M A Giamberardino; N Siliprandi
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2.  Acetyl-coenzyme a can regulate activity of the mitochondrial pyruvate dehydrogenase complex in situ.

Authors:  R J Budde; T K Fang; D D Randall; J A Miernyk
Journal:  Plant Physiol       Date:  1991-01       Impact factor: 8.340

3.  Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase.

Authors:  Qingling Li; Shuang Deng; Rafael A Ibarra; Vernon E Anderson; Henri Brunengraber; Guo-Fang Zhang
Journal:  J Biol Chem       Date:  2015-02-02       Impact factor: 5.157

Review 4.  Free fatty acid metabolism during myocardial ischemia and reperfusion.

Authors:  S C Hendrickson; J D St Louis; J E Lowe; S Abdel-aleem
Journal:  Mol Cell Biochem       Date:  1997-01       Impact factor: 3.396

5.  Fulminant Leigh syndrome and sudden unexpected death in a family with the T9176C mutation of the mitochondrial ATPase 6 gene.

Authors:  C Dionisi-Vici; S Seneca; M Zeviani; G Fariello; M Rimoldi; E Bertini; L De Meirleir
Journal:  J Inherit Metab Dis       Date:  1998-02       Impact factor: 4.982

6.  Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions.

Authors:  R Friolet; H Hoppeler; S Krähenbühl
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

Review 7.  Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency.

Authors:  Robert Ringseis; Janine Keller; Klaus Eder
Journal:  Eur J Nutr       Date:  2011-12-02       Impact factor: 5.614

8.  Carnitine and physical exercise.

Authors:  O J Heinonen
Journal:  Sports Med       Date:  1996-08       Impact factor: 11.136

9.  Effect of carboxylic acid xenobiotics and their metabolites on the activity of carnitine acyltransferases.

Authors:  D A Vessey; W W Chen; R R Ramsay
Journal:  Biochem J       Date:  1991-11-01       Impact factor: 3.857

10.  Changes in muscle free carnitine and acetylcarnitine with increasing work intensity in the Thoroughbred horse.

Authors:  R C Harris; C V Foster
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1990
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