Wilson Nascimento1, Gerson Ferrari2, Camila Bertini Martins1, Juan Pablo Rey-Lopez3,4, Mikel Izquierdo5, Dong Hoon Lee6, Edward L Giovannucci6,7,8, Leandro F M Rezende9. 1. Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina Preventiva, São Paulo, SP, Brazil. 2. Universidad de Santiago de Chile (USACH), Escuela de Ciencias de la Actividad Física, el Deporte y la Salud, Santiago, Chile. 3. Faculty of Health Sciences, International University of Valencia (VIU), Valencia, Spain. 4. Faculty of Sport, Catholic University San Antonio of Murcia, Murcia, Spain. 5. Navarrabiomed, Navarra Hospital Complex (NHC), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain. 6. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 7. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 8. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 9. Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina Preventiva, São Paulo, SP, Brazil. leandro.rezende@unifesp.br.
Abstract
BACKGROUND: Physical activity has been associated with reduced risk of seven types of cancer. It remains unclear, however, whether muscle-strengthening activities also reduce cancer incidence and mortality. METHODS: PubMed, Embase, Web of Science and Scopus were searched from inception to March 2020. Summary hazard ratio (HR) and 95% confidence intervals (CI) were estimated using random-effects models. RESULTS: Twelve studies (11 cohorts; 1 case-control), 6 to 25 years of follow-up, including 1,297,620 participants, 32,196 cases and 31,939 deaths, met inclusion criteria. Muscle-strengthening activities were associated with a 26% lower incidence of kidney cancer (HR for high vs low levels of muscle-strengthening activities: 0.74; 95% CI 0.56 to 0.98; I2 0%; 2 studies), but not with incidence of other 12 types of cancer. Muscle-strengthening activities were associated with lower total cancer mortality: HRs for high vs low levels of muscle-strengthening activities was 0.87 (95% CI 0.73 to 1.02; I2 58%; 6 studies); and HR for ≥2 times/week vs < 2 times/week of muscle-strengthening activities was 0.81 (95% CI 0.74 to 0.87; I2 0%; 4 studies). Regarding the weekly duration of muscle-strengthening activities, HR for total cancer mortality were 0.91 (95% CI 0.82 to 1.01; I2 0%; 2 studies) for 1-59 min/week and 0.98 (95% CI 0.89 to 1.07; I2 0%) for ≥60 min/week vs none. Combined muscle-strengthening and aerobic activities (vs none) were associated with a 28% lower total cancer mortality (HR 0.72; 95% CI 0.53 to 0.98; I2 85%; 3 studies). CONCLUSIONS: Muscle-strengthening activities were associated with reduced incidence of kidney cancer and total cancer mortality. Combined muscle-strengthening and aerobic activities may provide a greater reduction in total cancer mortality.
BACKGROUND: Physical activity has been associated with reduced risk of seven types of cancer. It remains unclear, however, whether muscle-strengthening activities also reduce cancer incidence and mortality. METHODS: PubMed, Embase, Web of Science and Scopus were searched from inception to March 2020. Summary hazard ratio (HR) and 95% confidence intervals (CI) were estimated using random-effects models. RESULTS: Twelve studies (11 cohorts; 1 case-control), 6 to 25 years of follow-up, including 1,297,620 participants, 32,196 cases and 31,939 deaths, met inclusion criteria. Muscle-strengthening activities were associated with a 26% lower incidence of kidney cancer (HR for high vs low levels of muscle-strengthening activities: 0.74; 95% CI 0.56 to 0.98; I2 0%; 2 studies), but not with incidence of other 12 types of cancer. Muscle-strengthening activities were associated with lower total cancer mortality: HRs for high vs low levels of muscle-strengthening activities was 0.87 (95% CI 0.73 to 1.02; I2 58%; 6 studies); and HR for ≥2 times/week vs < 2 times/week of muscle-strengthening activities was 0.81 (95% CI 0.74 to 0.87; I2 0%; 4 studies). Regarding the weekly duration of muscle-strengthening activities, HR for total cancer mortality were 0.91 (95% CI 0.82 to 1.01; I2 0%; 2 studies) for 1-59 min/week and 0.98 (95% CI 0.89 to 1.07; I2 0%) for ≥60 min/week vs none. Combined muscle-strengthening and aerobic activities (vs none) were associated with a 28% lower total cancer mortality (HR 0.72; 95% CI 0.53 to 0.98; I2 85%; 3 studies). CONCLUSIONS: Muscle-strengthening activities were associated with reduced incidence of kidney cancer and total cancer mortality. Combined muscle-strengthening and aerobic activities may provide a greater reduction in total cancer mortality.
Authors: Farzane Saeidifard; Jose R Medina-Inojosa; Colin P West; Thomas P Olson; Virend K Somers; Amanda R Bonikowske; Larry J Prokop; Manlio Vinciguerra; Francisco Lopez-Jimenez Journal: Eur J Prev Cardiol Date: 2019-05-19 Impact factor: 7.804
Authors: Emmanuel Stamatakis; I-Min Lee; Jason Bennie; Jonathan Freeston; Mark Hamer; Gary O'Donovan; Ding Ding; Adrian Bauman; Yorgi Mavros Journal: Am J Epidemiol Date: 2018-05-01 Impact factor: 4.897
Authors: Anne McTiernan; Christine M Friedenreich; Peter T Katzmarzyk; Kenneth E Powell; Richard Macko; David Buchner; Linda S Pescatello; Bonny Bloodgood; Bethany Tennant; Alison Vaux-Bjerke; Stephanie M George; Richard P Troiano; Katrina L Piercy Journal: Med Sci Sports Exerc Date: 2019-06 Impact factor: 5.411
Authors: Cheryl L Rock; Cynthia Thomson; Ted Gansler; Susan M Gapstur; Marjorie L McCullough; Alpa V Patel; Kimberly S Andrews; Elisa V Bandera; Colleen K Spees; Kimberly Robien; Sheri Hartman; Kristen Sullivan; Barbara L Grant; Kathryn K Hamilton; Lawrence H Kushi; Bette J Caan; Debra Kibbe; Jessica Donze Black; Tracy L Wiedt; Catherine McMahon; Kirsten Sloan; Colleen Doyle Journal: CA Cancer J Clin Date: 2020-06-09 Impact factor: 508.702
Authors: Alpa V Patel; Christine M Friedenreich; Steven C Moore; Sandra C Hayes; Julie K Silver; Kristin L Campbell; Kerri Winters-Stone; Lynn H Gerber; Stephanie M George; Janet E Fulton; Crystal Denlinger; G Stephen Morris; Trisha Hue; Kathryn H Schmitz; Charles E Matthews Journal: Med Sci Sports Exerc Date: 2019-11 Impact factor: 5.411
Authors: Leandro F M Rezende; Dong Hoon Lee; NaNa Keum; Kana Wu; José Eluf-Neto; Fred K Tabung; Edward L Giovannucci Journal: Br J Cancer Date: 2020-06-04 Impact factor: 7.640
Authors: Fiona C Bull; Salih S Al-Ansari; Stuart Biddle; Katja Borodulin; Matthew P Buman; Greet Cardon; Catherine Carty; Jean-Philippe Chaput; Sebastien Chastin; Roger Chou; Paddy C Dempsey; Loretta DiPietro; Ulf Ekelund; Joseph Firth; Christine M Friedenreich; Leandro Garcia; Muthoni Gichu; Russell Jago; Peter T Katzmarzyk; Estelle Lambert; Michael Leitzmann; Karen Milton; Francisco B Ortega; Chathuranga Ranasinghe; Emmanuel Stamatakis; Anne Tiedemann; Richard P Troiano; Hidde P van der Ploeg; Vicky Wari; Juana F Willumsen Journal: Br J Sports Med Date: 2020-12 Impact factor: 13.800
Authors: Yari Longobucco; Alice Masini; Sofia Marini; Giuseppe Barone; Carmela Fimognari; Laura Bragonzoni; Laura Dallolio; Francesca Maffei Journal: Oxid Med Cell Longev Date: 2022-02-18 Impact factor: 6.543
Authors: Wenyuan G Zhu; Jamie E Hibbert; Kuan Hung Lin; Nathaniel D Steinert; Jake L Lemens; Kent W Jorgenson; Sarah M Newman; Dudley W Lamming; Troy A Hornberger Journal: Cells Date: 2021-09-17 Impact factor: 6.600