Literature DB >> 34050832

On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy.

S A Kryzhanovskii1, L M Kozhevnikova2,3, M B Vititnova2, A O Efimova2, V N Stolyaruk2, I B Tsorin2.   

Abstract

The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy contributes to normalization of the expression of mRNA of genes of regulatory proteins СаМ (p=0.00001), Ерас1 (p=0.021), and Ерас2 (p=0.018) and receptors RyR2 (p=0.0031) and IP3R2 (p=0.006) in the myocardium of the myocardium of the left ventricle that is enhanced in control animals (p<0.05). These changes were accompanied by echocardiographically documented decrease in the degree of left ventricle remodeling and improvement of its inotropic function.

Entities:  

Keywords:  alcoholic cardiomyopathy; cardioprotection; echocardiography; expression of mRNA of the CaM, Erac1, Erac2, RyR2, and IP3R2 genes; fabomotizole

Mesh：

Substances：

Year:  2021        PMID： 34050832     DOI： 10.1007/s10517-021-05168-6

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

1.  Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.

Authors:  Emily A Oestreich; Huan Wang; Sundeep Malik; Katherine A Kaproth-Joslin; Burns C Blaxall; Grant G Kelley; Robert T Dirksen; Alan V Smrcka
Journal:  J Biol Chem       Date:  2006-12-17       Impact factor: 5.157

Review 2.  Molecules and roles of mitochondrial calcium signaling.

Authors:  Cristina Mammucari; Maria Patron; Veronica Granatiero; Rosario Rizzuto
Journal:  Biofactors       Date:  2011-06-14       Impact factor: 6.113

3.  Evidence of Echocardiography Validity in Model Experiments on Small Animals.

Authors:  S A Kryzhanovskii; L G Kolik; I B Tsorin; E O Ionova; V N Stolyaruk; A V Sorokina; M B Vititnova; I A Miroshkina
Journal:  Bull Exp Biol Med       Date:  2016-08-09       Impact factor: 0.804

4.  Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart.

Authors:  Sandeep S Hothi; Iman S Gurung; Jennifer C Heathcote; Yanmin Zhang; Stephen W Booth; Jeremy N Skepper; Andrew A Grace; Christopher L-H Huang
Journal:  Pflugers Arch       Date:  2008-07-04       Impact factor: 3.657

5.  Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes.

Authors:  Hideaki Tagashira; Md Shenuarin Bhuiyan; Kohji Fukunaga
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-08-09       Impact factor: 4.733

6.  Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger in Alcoholic Cardiomyopathy.

Authors:  L M Kozhevnikova; I B Tsorin; V N Stolyaruk; I F Sukhanova; M B Vititnova; T D Nikiforova; L G Kolik; S A Kryzhanovskii
Journal:  Bull Exp Biol Med       Date:  2018-09-17       Impact factor: 0.804

Review 7.  Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches.

Authors:  Felix Hohendanner; Andrew D McCulloch; Lothar A Blatter; Anushka P Michailova
Journal:  Front Pharmacol       Date:  2014-03-06       Impact factor: 5.810

Review 8.  Redox Dependent Modifications of Ryanodine Receptor: Basic Mechanisms and Implications in Heart Diseases.

Authors:  Roman Nikolaienko; Elisa Bovo; Aleksey V Zima
Journal:  Front Physiol       Date:  2018-12-06       Impact factor: 4.566
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.