Fabio Giovannelli1,2, Chiara Menichetti3, Lorenzo Kiferle4, Laura Maria Raglione2, Stefania Brotini5, Paola Vanni6, Duccio Bacci6, Mariella Baldini5, Alessandra Borgheresi2, Alessandra Del Bene3, Enrico Grassi4, Leonello Guidi5, Lucia Toscani6, Gino Volpi3, Pasquale Palumbo4, Maria Pia Viggiano1, Massimo Cincotta7. 1. Section of Psychology - Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), University of Florence, Florence, Italy. 2. Unit of Neurology of Florence, Cerebrovascular and Neurodegenerative Disease Area of the Department of Medical Specialties, Central Tuscany Local Health Authority, Florence, Italy. 3. Unit of Neurology of Pistoia, Cerebrovascular and Neurodegenerative Disease Area of the Department of Medical Specialties, Central Tuscany Local Health Authority, Florence, Italy. 4. Unit of Neurology of Prato, Cerebrovascular and Neurodegenerative Disease Area of the Department of Medical Specialties, Central Tuscany Local Health Authority, Florence, Italy. 5. Unit of Neurology of Empoli, Cerebrovascular and Neurodegenerative Disease Area of the Department of Medical Specialties, Central Tuscany Local Health Authority, Florence, Italy. 6. Unit of Neurology of Florence-OSMA, Cerebrovascular and Neurodegenerative Disease Area of the Department of Medical Specialties, Central Tuscany Local Health Authority, Florence, Italy. 7. Unit of Neurology of Florence, Cerebrovascular and Neurodegenerative Disease Area of the Department of Medical Specialties, Central Tuscany Local Health Authority, Florence, Italy. massimo.cincotta@uslcentro.toscana.it.
Abstract
INTRODUCTION: In patients with Parkinson's disease (PD), impulsivity is still a matter of investigation. It has been hypothesized that impulsive personality traits may favour impulse control disorder (ICD) onset during dopaminergic therapy. In healthy subjects, a relationship between the awareness of motor intention and impulsive personality traits assessed by the Barratt impulsivity scale (BIS-11) has been reported. The aim of this study was to evaluate the relationship between the awareness of voluntary action and impulsivity traits in PD. METHODS: Twenty-eight PD patients (stages I-III on the Hoehn and Yahr scale) underwent an impulsivity trait assessment by the BIS-11 scale and a task based on the Libet's clock. Participants were requested to perform a self-initiated movement and report the time they first feel their intention to move (W-judgement) or the time of the actual movement (M-judgement). RESULTS: In patients with higher BIS-11 scores, the time lag between the W-judgement and the actual movement was significantly lower than in patients with lower BIS-11. No difference emerged in the M-judgement. CONCLUSION: Data suggest that also in PD patients, the impulsive personality trait is related to a "delayed" awareness of motor intention and therefore to a shorter interval to allow a conscious "veto" of the impending action. Characterization of the temporal profile of awareness of motor intention could prove useful in identifying PD patients at risk of developing ICDs during dopaminergic treatment.
INTRODUCTION: In patients with Parkinson's disease (PD), impulsivity is still a matter of investigation. It has been hypothesized that impulsive personality traits may favour impulse control disorder (ICD) onset during dopaminergic therapy. In healthy subjects, a relationship between the awareness of motor intention and impulsive personality traits assessed by the Barratt impulsivity scale (BIS-11) has been reported. The aim of this study was to evaluate the relationship between the awareness of voluntary action and impulsivity traits in PD. METHODS: Twenty-eight PD patients (stages I-III on the Hoehn and Yahr scale) underwent an impulsivity trait assessment by the BIS-11 scale and a task based on the Libet's clock. Participants were requested to perform a self-initiated movement and report the time they first feel their intention to move (W-judgement) or the time of the actual movement (M-judgement). RESULTS: In patients with higher BIS-11 scores, the time lag between the W-judgement and the actual movement was significantly lower than in patients with lower BIS-11. No difference emerged in the M-judgement. CONCLUSION: Data suggest that also in PD patients, the impulsive personality trait is related to a "delayed" awareness of motor intention and therefore to a shorter interval to allow a conscious "veto" of the impending action. Characterization of the temporal profile of awareness of motor intention could prove useful in identifying PD patients at risk of developing ICDs during dopaminergic treatment.
Authors: Maddeson Riley; Megan Bakeberg; Michelle Byrnes; Alexa Jefferson; Soumya Ghosh; Rick Stell; Frank L Mastaglia; Dana Hince; Ryan S Anderton Journal: Parkinsons Dis Date: 2018-04-19