Literature DB >> 34050415

Drug Resistance of Mouse Somatic Cells to Rifampicin in Experimental Tuberculosis.

B V Nikonenko1, I V Bocharova2, L N Lepekha2.   

Abstract

We have demonstrated that long-term exposure of intact mice to rifampicin (6 months) induces resistance to this drug, which manifested in inability of rifampicin to suppress the growth of Mycobacterium tuberculosis in the lungs and spleen during subsequent infection. It the same time, isoniazid is still effective in these mice. In this case, the phenomenon of somatic resistance to rifampicin in mice was observed if the treatment was started in a short period (within 4 days) after infection with M. tuberculosis. If the interval between infection and rifampicin administration was longer (3 weeks), the resistance disappeared.

Entities:  

Keywords:  drug resistance of somatic cells; inbred mice; isoniazid; rifampicin; tuberculous inflammation

Mesh：

Substances：

Year:  2021        PMID： 34050415     DOI： 10.1007/s10517-021-05171-x

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

1.  A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.

Authors:  Koen Andries; Peter Verhasselt; Jerome Guillemont; Hinrich W H Göhlmann; Jean-Marc Neefs; Hans Winkler; Jef Van Gestel; Philip Timmerman; Min Zhu; Ennis Lee; Peter Williams; Didier de Chaffoy; Emma Huitric; Sven Hoffner; Emmanuelle Cambau; Chantal Truffot-Pernot; Nacer Lounis; Vincent Jarlier
Journal:  Science       Date:  2004-12-09       Impact factor: 47.728

2.  Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3).

Authors:  B I Florea; I C van der Sandt; S M Schrier; K Kooiman; K Deryckere; A G de Boer; H E Junginger; G Borchard
Journal:  Br J Pharmacol       Date:  2001-12       Impact factor: 8.739

3.  Rapid, simple in vivo screen for new drugs active against Mycobacterium tuberculosis.

Authors:  Boris V Nikonenko; Rowena Samala; Leo Einck; Carol A Nacy
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

4.  P-glycoprotein efflux pump expression and activity in Calu-3 cells.

Authors:  K O Hamilton; G Backstrom; M A Yazdanian; K L Audus
Journal:  J Pharm Sci       Date:  2001-05       Impact factor: 3.534

Review 5.  ABC transporters as mediators of drug resistance and contributors to cancer cell biology.

Authors:  Jamie I Fletcher; Rebekka T Williams; Michelle J Henderson; Murray D Norris; Michelle Haber
Journal:  Drug Resist Updat       Date:  2016-03-17       Impact factor: 18.500
  5 in total

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